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Acepromazine

PromAce, Atravet

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Sedative

Routes

POIMIVSC

Indications

Mild sedationPre-anesthetic sedation

Mechanism of Action

Blocks dopamine D2 receptors in the CNS, producing sedation and anxiolysis. Also has alpha-1 adrenergic blocking properties causing vasodilation.

Side effects & warnings

Hypotension (alpha blockade) — avoid in hypovolemic patients. DO NOT use in giant breeds (boxers extremely sensitive — exaggerated hypotension). No analgesic effect. Lowers seizure threshold. Not reversible.

Species with Acepromazine dosing data (3 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs

Evidence levels across 3 dose rules

Moderate×1Strong×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 3 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)IM0.01–0.05 mg/kgSingle doseStrongPlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)IM0.05–0.1 mg/kgSingle doseStrongPlumb's Veterinary Drug Handbook, 9th Ed

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Calculate Dosage for Acepromazine