ExoticRx · exoticrx.com/drugs/acepromazine
US brand names:PromAce, Atravet
Acepromazine is dosed at 0.05–0.1 mg/kg IM Single dose in cats, per Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.33 (2026-08-01).. Verify against current literature before clinical use.
Blocks dopamine D2 receptors in the CNS, producing sedation and anxiolysis. Also has alpha-1 adrenergic blocking properties causing vasodilation.
Hypotension (alpha blockade) — avoid in hypovolemic patients. DO NOT use in giant breeds (boxers extremely sensitive — exaggerated hypotension). No analgesic effect. Lowers seizure threshold. Not reversible.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Cat (Domestic) | IM | 0.05–0.1 mg/kg | Single dose | Strong | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.33 (2026-08-01). |
| Dog (Domestic) | IM | 0.01–0.05 mg/kg | Single dose | Strong | Allerton F, ed. BSAVA Small Animal Formulary Part A: Canine and Feline. 10th ed. BSAVA; 2020. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.33 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.