ExoticRx · exoticrx.com/drugs/metolazone
US brand names:Zaroxolyn
Metolazone is dosed at 0.1–0.5 mg/kg PO q12-24h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Quinazoline diuretic that inhibits sodium reabsorption in the distal convoluted tubule. Retains efficacy in renal impairment unlike true thiazides.
Potent diuretic synergy with loop diuretics — severe electrolyte depletion. Monitor potassium, sodium, magnesium. Used for furosemide-resistant CHF.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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