ExoticRx · exoticrx.com/drugs/milrinone
US brand names:Primacor
Milrinone is dosed at 1–3 mcg/kg/min IV CRI in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Inhibits phosphodiesterase III increasing intracellular cAMP. Positive inotrope and vasodilator (inodilator). Does not increase myocardial oxygen demand as much as catecholamines.
IV CRI only. Hypotension possible. Arrhythmogenic. Monitor ECG and blood pressure. Thrombocytopenia reported. Limited veterinary data.
Species references:All Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Milrinone CRI dose rule from the ExoticRx formulary. Verify against current literature before clinical use; CRI rates differ from bolus dosing and route, dilution, and monitoring matter. Sign in for the complete per-species CRI protocol set.
| Species | Route | Rate | Indication | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1–3 mcg/kg/minCRI | Acute heart failure (short-term) | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
Acute heart failure (short-term)
A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 1–3 mcg/kg/min | CRI | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.