Cat · Felis catus · typical adult weight 2.50–7.00 kg
Neostigmine is dosed at 0.02–0.04 mg/kg IV Single IV dose with glycopyrrolate in cats, per Cridge H, Little A, José-López R, et al. The clinical utility of neostigmine administration in the diagnosis of acquired myasthenia gravis. J Vet Emerg Crit Care. 2021;31(5):647-655. doi:10.1111/vec.13097 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.958 (2026-08-01).. Neostigmine is used in cats for Reversal of non-depolarizing NMB agents. Routes documented in cats: IV. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Neostigmine in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Prostigmin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.02–0.04 mg/kg | Single IV dose with glycopyrrolate | Single dose; onset 2-5 minutes | Reversal of non-depolarizing NMB agents | Moderate | Cridge H, Little A, José-López R, et al. The clinical utility of neostigmine administration in the diagnosis of acquired myasthenia gravis. J Vet Emerg Crit Care. 2021;31(5):647-655. doi:10.1111/vec.13097 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.958 (2026-08-01). |
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Reversible acetylcholinesterase inhibitor that does not cross blood-brain barrier. Increases acetylcholine at neuromuscular junction for reversal of non-depolarizing NMB agents.
Always co-administer with atropine or glycopyrrolate to prevent muscarinic side effects (bradycardia, salivation). Overdose can cause cholinergic crisis.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Neostigmine dose range in cats, with cited source references: IV 0.02–0.04 mg/kg Single IV dose with glycopyrrolate. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Neostigmine in cats: IV.
Cited course lengths for Neostigmine in cats include: Single dose; onset 2-5 minutes. Duration depends on the indication — match it to the specific dose rule in the table above.
Neostigmine is indicated in cats for: Reversal of non-depolarizing NMB agents.
These are general warnings for Neostigmine across species; consult the cat dosing table above for species-specific guidance. Always co-administer with atropine or glycopyrrolate to prevent muscarinic side effects (bradycardia, salivation). Overdose can cause cholinergic crisis.
Why a species-specific page? Neostigmine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.