Cat · Felis catus · typical adult weight 2.50–7.00 kg
Neostigmine is dosed at 0.02–0.04 mg/kg IV Single IV dose with glycopyrrolate in cats, per Cridge H, Little A, José-López R, et al. The clinical utility of neostigmine administration in the diagnosis of acquired myasthenia gravis. J Vet Emerg Crit Care. 2021;31(5):647-655. doi:10.1111/vec.13097 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.958 (2026-08-01). — Plumb's 10th ed (held) printed p.930, Neostigmine monograph spanning p.930-931; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Neostigmine is used in cats for Reversal of non-depolarizing NMB agents. Routes documented in cats: IV. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Neostigmine in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Prostigmin
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.02–0.04 mg/kg | Single IV dose with glycopyrrolate | Single dose; onset 2-5 minutes |
| Reversal of non-depolarizing NMB agents |
| Moderate |
| Cridge H, Little A, José-López R, et al. The clinical utility of neostigmine administration in the diagnosis of acquired myasthenia gravis. J Vet Emerg Crit Care. 2021;31(5):647-655. doi:10.1111/vec.13097 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.958 (2026-08-01). — Plumb's 10th ed (held) printed p.930, Neostigmine monograph spanning p.930-931; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mcg/kg) | Route | Source | As printed |
|---|---|---|---|
| 10 | IM | Papich Saunders Handbook of Veterinary Drugs, 4th edp.589 | • Antimyasthenic treatment: 10 mcg/kg IM or SQ as needed. |
| 40 | IM | Papich Saunders Handbook of Veterinary Drugs, 4th edp.589 | • Diagnostic aid for myasthenia: 40 mcg/kg IM or 20 mcg/kg IV. |
| 20 | IM | Papich Saunders Handbook of Veterinary Drugs, 4th edp.589 | • Diagnostic aid for myasthenia: 40 mcg/kg IM or 20 mcg/kg IV. |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
Need the exact dose for your patient?
These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Reversible acetylcholinesterase inhibitor that does not cross blood-brain barrier. Increases acetylcholine at neuromuscular junction for reversal of non-depolarizing NMB agents.
Always co-administer with atropine or glycopyrrolate to prevent muscarinic side effects (bradycardia, salivation). Overdose can cause cholinergic crisis.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Neostigmine dose range in cats, with cited source references: IV 0.02–0.04 mg/kg Single IV dose with glycopyrrolate. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Neostigmine in cats: IV.
Cited course lengths for Neostigmine in cats include: Single dose; onset 2-5 minutes. Duration depends on the indication — match it to the specific dose rule in the table above.
Neostigmine is indicated in cats for: Reversal of non-depolarizing NMB agents.
These are general warnings for Neostigmine across species; consult the cat dosing table above for species-specific guidance. Always co-administer with atropine or glycopyrrolate to prevent muscarinic side effects (bradycardia, salivation). Overdose can cause cholinergic crisis.
Why a species-specific page? Neostigmine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 2 |
| PO |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.589 |
| • 2 mg/kg per day PO in divided doses. N |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.