ExoticRx · exoticrx.com/drugs/neostigmine
US brand names:Prostigmin
Neostigmine is dosed at 0.02–0.04 mg/kg IV Single IV dose with atropine/glycopyrrolate in dogs, per Jones RS, Auer U, Mosing M. Reversal of neuromuscular block in companion animals. Vet Anaesth Analg. 2015;42(5):455-471. doi:10.1111/vaa.12272 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.958 (2026-08-01).. Verify against current literature before clinical use.
Reversible acetylcholinesterase inhibitor that does not cross blood-brain barrier. Increases acetylcholine at neuromuscular junction for reversal of non-depolarizing NMB agents.
Always co-administer with atropine or glycopyrrolate to prevent muscarinic side effects (bradycardia, salivation). Overdose can cause cholinergic crisis.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.02–0.04 mg/kg | Single IV dose with atropine/glycopyrrolate | Strong | Jones RS, Auer U, Mosing M. Reversal of neuromuscular block in companion animals. Vet Anaesth Analg. 2015;42(5):455-471. doi:10.1111/vaa.12272 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.958 (2026-08-01). |
| Cat (Domestic) | IV | 0.02–0.04 mg/kg | Single IV dose with glycopyrrolate | Moderate | Cridge H, Little A, José-López R, et al. The clinical utility of neostigmine administration in the diagnosis of acquired myasthenia gravis. J Vet Emerg Crit Care. 2021;31(5):647-655. doi:10.1111/vec.13097 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.958 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.