Cat · Felis catus · typical adult weight 2.50–7.00 kg
Physostigmine is dosed at 0.01–0.02 mg/kg IV Slow IV push; may repeat q15-30min in cats, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1022, Physostigmine monograph spanning p.1022-1023; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Physostigmine is used in cats for Anticholinergic toxicity. Routes documented in cats: IV. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Physostigmine in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Antilirium
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.01–0.02 mg/kg | Slow IV push; may repeat q15-30min | Short acting; titrate to effect | Anticholinergic toxicity | Weak | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Plumb's 10th ed (held) printed p.1022, Physostigmine monograph spanning p.1022-1023; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.02 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.664 | • 0.02 mg/kg q12h IV. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Reversible carbamate acetylcholinesterase inhibitor that crosses the blood-brain barrier, reversing both central and peripheral anticholinergic toxicity.
Short duration of action — repeat dosing often needed. Can cause cholinergic crisis. Atropine must be available as counter-antidote. Slow IV push only.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Physostigmine dose range in cats, with cited source references: IV 0.01–0.02 mg/kg Slow IV push; may repeat q15-30min. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Physostigmine in cats: IV.
Cited course lengths for Physostigmine in cats include: Short acting; titrate to effect. Duration depends on the indication — match it to the specific dose rule in the table above.
Physostigmine is indicated in cats for: Anticholinergic toxicity.
These are general warnings for Physostigmine across species; consult the cat dosing table above for species-specific guidance. Short duration of action — repeat dosing often needed. Can cause cholinergic crisis. Atropine must be available as counter-antidote. Slow IV push only.
Why a species-specific page? Physostigmine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.