Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Physostigmine is used in dog for Anticholinergic toxicity (e.g., jimsonweed, antihistamine OD). Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Physostigmine in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Antilirium
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.01–0.02 mg/kg | Slow IV push; may repeat q15-30min | Short duration of action (20-60 min); may need multiple doses | Anticholinergic toxicity (e.g., jimsonweed, antihistamine OD) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed; ASPCA Toxicology |
Absolute dose ceiling, regardless of body weight: 2 mg total (IV).
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Reversible carbamate acetylcholinesterase inhibitor that crosses the blood-brain barrier, reversing both central and peripheral anticholinergic toxicity.
Short duration of action — repeat dosing often needed. Can cause cholinergic crisis. Atropine must be available as counter-antidote. Slow IV push only.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Physostigmine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.