Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Physostigmine is dosed at 0.01–0.02 mg/kg IV Slow IV push; may repeat q15-30min in dogs, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted); ASPCA Toxicology — Plumb's 10th ed (held) printed p.1022, Physostigmine monograph spanning p.1022-1023; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Physostigmine is used in dogs for Anticholinergic toxicity (e.g., jimsonweed, antihistamine OD). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Physostigmine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Antilirium
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.01–0.02 mg/kg | Slow IV push; may repeat q15-30min | Short duration of action (20-60 min); may need multiple doses | Anticholinergic toxicity (e.g., jimsonweed, antihistamine OD) | Moderate | Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted); ASPCA Toxicology — Plumb's 10th ed (held) printed p.1022, Physostigmine monograph spanning p.1022-1023; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.02 | IV | Papich Saunders Handbook of Veterinary Drugs, 4th edp.664 | • 0.02 mg/kg q12h IV. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Reversible carbamate acetylcholinesterase inhibitor that crosses the blood-brain barrier, reversing both central and peripheral anticholinergic toxicity.
Short duration of action — repeat dosing often needed. Can cause cholinergic crisis. Atropine must be available as counter-antidote. Slow IV push only.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Physostigmine dose range in dogs, with cited source references: IV 0.01–0.02 mg/kg Slow IV push; may repeat q15-30min. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Physostigmine in dogs: IV.
Cited course lengths for Physostigmine in dogs include: Short duration of action (20-60 min); may need multiple doses. Duration depends on the indication — match it to the specific dose rule in the table above.
Physostigmine is indicated in dogs for: Anticholinergic toxicity (e.g., jimsonweed, antihistamine OD).
These are general warnings for Physostigmine across species; consult the dog dosing table above for species-specific guidance. Short duration of action — repeat dosing often needed. Can cause cholinergic crisis. Atropine must be available as counter-antidote. Slow IV push only.
Why a species-specific page? Physostigmine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.