Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Physostigmine is dosed at 0.01–0.02 mg/kg IV Slow IV push; may repeat q15-30min in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed; ASPCA Toxicology. Physostigmine is used in dogs for Anticholinergic toxicity (e.g., jimsonweed, antihistamine OD). Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Physostigmine in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Antilirium
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.01–0.02 mg/kgmax 2 mg total | Slow IV push; may repeat q15-30min | Short duration of action (20-60 min); may need multiple doses | Anticholinergic toxicity (e.g., jimsonweed, antihistamine OD) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed; ASPCA Toxicology |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Reversible carbamate acetylcholinesterase inhibitor that crosses the blood-brain barrier, reversing both central and peripheral anticholinergic toxicity.
Short duration of action — repeat dosing often needed. Can cause cholinergic crisis. Atropine must be available as counter-antidote. Slow IV push only.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Physostigmine dose range in dogs, with cited source references: IV 0.01–0.02 mg/kg Slow IV push; may repeat q15-30min. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Physostigmine in dogs: IV.
Cited course lengths for Physostigmine in dogs include: Short duration of action (20-60 min); may need multiple doses. Duration depends on the indication — match it to the specific dose rule in the table above.
Physostigmine is indicated in dogs for: Anticholinergic toxicity (e.g., jimsonweed, antihistamine OD).
These are general warnings for Physostigmine across species; consult the dog dosing table above for species-specific guidance. Short duration of action — repeat dosing often needed. Can cause cholinergic crisis. Atropine must be available as counter-antidote. Slow IV push only.
Why a species-specific page? Physostigmine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.