ExoticRx · exoticrx.com/drugs/physostigmine
US brand names:Antilirium
Physostigmine is dosed at 0.01–0.02 mg/kg IV Slow IV push; may repeat q15-30min in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed; ASPCA Toxicology. Verify against current literature before clinical use.
Reversible carbamate acetylcholinesterase inhibitor that crosses the blood-brain barrier, reversing both central and peripheral anticholinergic toxicity.
Short duration of action — repeat dosing often needed. Can cause cholinergic crisis. Atropine must be available as counter-antidote. Slow IV push only.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.