ExoticRx · exoticrx.com/drugs/nintedanib
US brand names:Ofev
Nintedanib is dosed at 2–5 mg/kg PO q12h in dogs, per Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.. Verify against current literature before clinical use.
Triple angiokinase inhibitor blocking VEGFR, FGFR, and PDGFR tyrosine kinases, reducing fibroblast migration, proliferation, and extracellular matrix deposition.
Diarrhea most common side effect. Hepatotoxicity risk — monitor LFTs. Bleeding risk. Investigational for pulmonary fibrosis in dogs.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 2–5 mg/kg | q12h | Weak | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
| Cat (Domestic) | PO | 2–4 mg/kg | q12h | Extrapolated | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.