Pocket Pet · Mus musculus · typical adult weight 0.02–0.04 kg
Pentobarbital is dosed at 40–70 mg/kg IP See source in mouses, per Oh SS, Narver HL. Mouse and Rat Anesthesia and Analgesia. Curr Protoc. 2024 Feb;4(2):e995. doi:10.1002/cpz1.995. PMID: 38406895; PMCID: PMC10914332. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10914332/. Pentobarbital is used in mouses for Injectable anesthesia (duration of anesthesia 10-300 min). Routes documented in mouses: IP. A typical adult mouse weighs 0.02–0.04 kg. ExoticRx lists 1 cited dose rule for Pentobarbital in mouses, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Nembutal
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IP | 40–70 mg/kg | See source | Injectable anesthesia (duration of anesthesia 10-300 min) | Weak | Oh SS, Narver HL. Mouse and Rat Anesthesia and Analgesia. Curr Protoc. 2024 Feb;4(2):e995. doi:10.1002/cpz1.995. PMID: 38406895; PMCID: PMC10914332. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10914332/ |
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Barbiturate enhancing GABA-A receptor activity and directly activating GABA receptor at high doses. Dose-dependent CNS depression from sedation to death.
DEA Schedule II. Primary component of euthanasia solutions. Controlled substance requiring DEA registration. Rapid IV causes apnea — give slowly for anesthetic use.
Species-specific contraindications and adverse-reaction reports for mouses may differ from canine / feline reference data — consult the primary citations listed with each rule.
Pentobarbital dose range in mouses, with cited source references: IP 40–70 mg/kg See source.
Documented routes for Pentobarbital in mouses: IP.
Pentobarbital is indicated in mouses for: Injectable anesthesia (duration of anesthesia 10-300 min).
These are general warnings for Pentobarbital across species; consult the mouse dosing table above for species-specific guidance. DEA Schedule II. Primary component of euthanasia solutions. Controlled substance requiring DEA registration. Rapid IV causes apnea — give slowly for anesthetic use.
Why a species-specific page? Pentobarbital pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in mouses — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.