Pocket Pet · Mus musculus · typical adult weight 0.02–0.04 kg
Pentobarbital is dosed at 40–70 mg/kg IP not stated in the cited source in mice, per Oh SS, Narver HL. Mouse and Rat Anesthesia and Analgesia. Curr Protoc. 2024 Feb;4(2):e995. doi:10.1002/cpz1.995. PMID: 38406895; PMCID: PMC10914332. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10914332/. Pentobarbital is used in mice for Injectable anesthesia (duration of anesthesia 10-300 min). Routes documented in mice: IP. A typical adult mouse weighs 0.02–0.04 kg. ExoticRx lists 1 cited dose rule for Pentobarbital in mice, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Nembutal
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| IP | 40–70 mg/kg | not stated in the cited source | Injectable anesthesia (duration of anesthesia 10-300 min) |
| Weak |
| Oh SS, Narver HL. Mouse and Rat Anesthesia and Analgesia. Curr Protoc. 2024 Feb;4(2):e995. doi:10.1002/cpz1.995. PMID: 38406895; PMCID: PMC10914332. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10914332/ |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 150 | IV | BSAVA Small Animal Formulary, 10th ed — Part B (Exotic Pets)p.244 | 150 mg/kg i.v., i.p. as rapidly as possible or to effect |
| 50 | IP | Carpenter's Exotic Animal Formulary, 6th edTable 9.3 | 50 mg/kg IP |
| 50–90 | IP | Carpenter's Exotic Animal Formulary, 6th edTable 9.3 | 50-90 mg/kg IP |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your mouse's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Barbiturate enhancing GABA-A receptor activity and directly activating GABA receptor at high doses. Dose-dependent CNS depression from sedation to death.
DEA Schedule II. Primary component of euthanasia solutions. Controlled substance requiring DEA registration. Rapid IV causes apnea — give slowly for anesthetic use.
Species-specific contraindications and adverse-reaction reports for mice may differ from canine / feline reference data — consult the primary citations listed with each rule.
Pentobarbital dose range in mice, with cited source references: IP 40–70 mg/kg not stated in the cited source. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Pentobarbital in mice: IP.
Pentobarbital is indicated in mice for: Injectable anesthesia (duration of anesthesia 10-300 min).
These are general warnings for Pentobarbital across species; consult the mouse dosing table above for species-specific guidance. DEA Schedule II. Primary component of euthanasia solutions. Controlled substance requiring DEA registration. Rapid IV causes apnea — give slowly for anesthetic use.
Why a species-specific page? Pentobarbital pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in mice — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.