ExoticRx · exoticrx.com/drugs/pentobarbital
US brand names:Nembutal
Pentobarbital is dosed at 40–70 mg/kg IP See source in mice, per Oh SS, Narver HL. Mouse and Rat Anesthesia and Analgesia. Curr Protoc. 2024 Feb;4(2):e995. doi:10.1002/cpz1.995. PMID: 38406895; PMCID: PMC10914332. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC10914332/. Verify against current literature before clinical use.
Barbiturate enhancing GABA-A receptor activity and directly activating GABA receptor at high doses. Dose-dependent CNS depression from sedation to death.
DEA Schedule II. Primary component of euthanasia solutions. Controlled substance requiring DEA registration. Rapid IV causes apnea — give slowly for anesthetic use.
Species references:All Mouse drugs
Controlled substance in the US
Controlled-drug status and schedules differ by country — check your local scheduling rules.
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