Cat · Felis catus · typical adult weight 2.50–7.00 kg
Pentosan Polysulfate is dosed at 3 mg/kg SC once weekly for 4 weeks in cats, per Plumb's Veterinary Drug Handbook, 10th Ed (HELD), Pentosan Polysulfate (PPS), Dosages/CATS, printed p.1000 (corpus p.1028); dose corroborated by BSAVA 10th printed p.311 (corpus p.327). Pentosan Polysulfate is used in cats for Feline interstitial cystitis (FIC). Routes documented in cats: SC. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Pentosan Polysulfate in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Cartrophen Vet, Elmiron
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| SC | 3 mg/kg | once weekly for 4 weeks | 4-dose series | Feline interstitial cystitis (FIC) | Moderate | Plumb's Veterinary Drug Handbook, 10th Ed (HELD), Pentosan Polysulfate (PPS), Dosages/CATS, printed p.1000 (corpus p.1028); dose corroborated by BSAVA 10th printed p.311 (corpus p.327) |
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Semi-synthetic polysulfated xylanopyranose. Stimulates proteoglycan synthesis, inhibits catabolic enzymes, improves blood flow to subchondral bone.
SC injection series for OA (weekly x 4). May affect coagulation. Also used for feline interstitial cystitis (oral). Not available in USA (available in Australia, EU).
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Pentosan Polysulfate dose range in cats, with cited source references: SC 3 mg/kg once weekly for 4 weeks. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Pentosan Polysulfate in cats: SC.
Cited course lengths for Pentosan Polysulfate in cats include: 4-dose series. Duration depends on the indication — match it to the specific dose rule in the table above.
Pentosan Polysulfate is indicated in cats for: Feline interstitial cystitis (FIC).
These are general warnings for Pentosan Polysulfate across species; consult the cat dosing table above for species-specific guidance. SC injection series for OA (weekly x 4). May affect coagulation. Also used for feline interstitial cystitis (oral). Not available in USA (available in Australia, EU).
Why a species-specific page? Pentosan Polysulfate pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.