Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Pentosan Polysulfate is dosed at 3 mg/kg SC weekly x 4 in dogs, per Budsberg SC, Bergh MS, Reynolds LR et al. (2007) Evaluation of pentosan polysulfate sodium in the postoperative recovery from cranial cruciate injury in dogs: a randomized, placebo-controlled clinical trial. Veterinary Surgery 36, 234-244 doi:10.1111/j.1532-950x.2007.00256.x — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.327 (2026-08-01).. Pentosan Polysulfate is used in dogs for Osteoarthritis. Routes documented in dogs: SC. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Pentosan Polysulfate in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Cartrophen Vet, Elmiron
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| SC | 3 mg/kg | weekly x 4 | 4-dose series | Osteoarthritis | Moderate | Budsberg SC, Bergh MS, Reynolds LR et al. (2007) Evaluation of pentosan polysulfate sodium in the postoperative recovery from cranial cruciate injury in dogs: a randomized, placebo-controlled clinical trial. Veterinary Surgery 36, 234-244 doi:10.1111/j.1532-950x.2007.00256.x — Verified against BSAVA Small Animal Formulary, 10th Ed, Part A, p.327 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Semi-synthetic polysulfated xylanopyranose. Stimulates proteoglycan synthesis, inhibits catabolic enzymes, improves blood flow to subchondral bone.
SC injection series for OA (weekly x 4). May affect coagulation. Also used for feline interstitial cystitis (oral). Not available in USA (available in Australia, EU).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Pentosan Polysulfate dose range in dogs, with cited source references: SC 3 mg/kg weekly x 4. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Pentosan Polysulfate in dogs: SC.
Cited course lengths for Pentosan Polysulfate in dogs include: 4-dose series. Duration depends on the indication — match it to the specific dose rule in the table above.
Pentosan Polysulfate is indicated in dogs for: Osteoarthritis.
These are general warnings for Pentosan Polysulfate across species; consult the dog dosing table above for species-specific guidance. SC injection series for OA (weekly x 4). May affect coagulation. Also used for feline interstitial cystitis (oral). Not available in USA (available in Australia, EU).
Why a species-specific page? Pentosan Polysulfate pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.