Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Zoledronic Acid is dosed at 0.1–0.25 mg/kg IV once q28 days in dogs, per Garrett RL, Selmic LE, Kamerer TM, Fan TM. Accelerated Radiation Therapy and Zoledronate for Osteosarcoma Bone Pain. Presented at: American College of Veterinary Internal Medicine Forum; 2014. | Schenk A, Lux C, Lane J, Martin O. Evaluation of Zoledronate as Treatment for Hypercalcemia in Four Dogs. J Am Anim Hosp Assoc. 2018;54(6):e54604. | Brewer DJ, Macfarlane M, O'Connell E, Bacon NJ. Toxicity of zoledronic acid after intravenous administration: A retrospective study of 95 dogs. J Vet Intern Med. 2022;36(1):253-258. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1357 (2026-08-01).. Zoledronic Acid is used in dogs for Hypercalcemia of malignancy, bone metastases. Routes documented in dogs: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Zoledronic Acid in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Zometa, Reclast
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.1–0.25 mg/kg | once q28 days | Variable | Hypercalcemia of malignancy, bone metastases | Moderate | Garrett RL, Selmic LE, Kamerer TM, Fan TM. Accelerated Radiation Therapy and Zoledronate for Osteosarcoma Bone Pain. Presented at: American College of Veterinary Internal Medicine Forum; 2014. | Schenk A, Lux C, Lane J, Martin O. Evaluation of Zoledronate as Treatment for Hypercalcemia in Four Dogs. J Am Anim Hosp Assoc. 2018;54(6):e54604. | Brewer DJ, Macfarlane M, O'Connell E, Bacon NJ. Toxicity of zoledronic acid after intravenous administration: A retrospective study of 95 dogs. J Vet Intern Med. 2022;36(1):253-258. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1357 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Most potent bisphosphonate available. Inhibits farnesyl diphosphate synthase in mevalonate pathway disrupting osteoclast function.
Single IV infusion. Used for hypercalcemia of malignancy and bone metastases in dogs. Nephrotoxic — ensure adequate hydration. Jaw osteonecrosis rare. Acute phase reaction (fever, myalgia).
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Zoledronic Acid dose range in dogs, with cited source references: IV 0.1–0.25 mg/kg once q28 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Zoledronic Acid in dogs: IV.
Cited course lengths for Zoledronic Acid in dogs include: Variable. Duration depends on the indication — match it to the specific dose rule in the table above.
Zoledronic Acid is indicated in dogs for: Hypercalcemia of malignancy, bone metastases.
These are general warnings for Zoledronic Acid across species; consult the dog dosing table above for species-specific guidance. Single IV infusion. Used for hypercalcemia of malignancy and bone metastases in dogs. Nephrotoxic — ensure adequate hydration. Jaw osteonecrosis rare. Acute phase reaction (fever, myalgia).
Why a species-specific page? Zoledronic Acid pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.