Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Zoledronic Acid is used in dog for Hypercalcemia of malignancy, bone metastases. Routes documented in dog: IV. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Zoledronic Acid in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Zometa, Reclast
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IV | 0.1–0.25 mg/kg | once q28 days | Variable | Hypercalcemia of malignancy, bone metastases | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Most potent bisphosphonate available. Inhibits farnesyl diphosphate synthase in mevalonate pathway disrupting osteoclast function.
Single IV infusion. Used for hypercalcemia of malignancy and bone metastases in dogs. Nephrotoxic — ensure adequate hydration. Jaw osteonecrosis rare. Acute phase reaction (fever, myalgia).
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Zoledronic Acid pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.