ExoticRx · exoticrx.com/drugs/zoledronic-acid
Zometa, Reclast
Most potent bisphosphonate available. Inhibits farnesyl diphosphate synthase in mevalonate pathway disrupting osteoclast function.
Single IV infusion. Used for hypercalcemia of malignancy and bone metastases in dogs. Nephrotoxic — ensure adequate hydration. Jaw osteonecrosis rare. Acute phase reaction (fever, myalgia).
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IV | 0.1–0.25 mg/kg | once q28 days | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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