Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Polysulfated Glycosaminoglycan is dosed at 4.4 mg/kg IM q3-5 days x 8 injections in dogs, per Adequan Canine- Polysulfated Glycosaminoglycan Injection, Solution [Package Insert]. American Regent, Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1edcf949-d6de-4921-815d-f86ccf084cae — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1067 (2026-08-01).. Polysulfated Glycosaminoglycan is used in dogs for Osteoarthritis. Routes documented in dogs: IM. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Polysulfated Glycosaminoglycan in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Adequan Canine, Adequan Equine
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 4.4 mg/kg | q3-5 days x 8 injections | 8-injection series | Osteoarthritis | Strong |
| Adequan Canine- Polysulfated Glycosaminoglycan Injection, Solution [Package Insert]. American Regent, Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1edcf949-d6de-4921-815d-f86ccf084cae — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1067 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits catabolic enzymes (metalloproteinases, serine proteases) in cartilage. Stimulates proteoglycan and hyaluronic acid synthesis. Anti-inflammatory in joints.
FDA-approved for dogs and horses. IM injection series (usually 8 doses over 4 weeks). May affect coagulation — avoid in patients on anticoagulants. Injection site reactions.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Polysulfated Glycosaminoglycan dose range in dogs, with cited source references: IM 4.4 mg/kg q3-5 days x 8 injections. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Polysulfated Glycosaminoglycan in dogs: IM.
Cited course lengths for Polysulfated Glycosaminoglycan in dogs include: 8-injection series. Duration depends on the indication — match it to the specific dose rule in the table above.
Polysulfated Glycosaminoglycan is indicated in dogs for: Osteoarthritis.
These are general warnings for Polysulfated Glycosaminoglycan across species; consult the dog dosing table above for species-specific guidance. FDA-approved for dogs and horses. IM injection series (usually 8 doses over 4 weeks). May affect coagulation — avoid in patients on anticoagulants. Injection site reactions.
Why a species-specific page? Polysulfated Glycosaminoglycan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.