Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Polysulfated Glycosaminoglycan is dosed at 4.4 mg/kg IM twice weekly (q3-4d) up to 4 wk, max 8 injections in dogs, per Adequan Canine- Polysulfated Glycosaminoglycan Injection, Solution [Package Insert]. American Regent, Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1edcf949-d6de-4921-815d-f86ccf084cae — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1067 (2026-08-01). — Plumb's 10th ed (held) printed p.1040, Polysulfated Glycosaminoglycan monograph spanning p.1039-1040; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Polysulfated Glycosaminoglycan is used in dogs for Osteoarthritis. Routes documented in dogs: IM. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Polysulfated Glycosaminoglycan in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Adequan Canine, Adequan Equine
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 4.4 mg/kg | twice weekly (q3-4d) up to 4 wk, max 8 injections | 8-injection series | Osteoarthritis | Strong | Adequan Canine- Polysulfated Glycosaminoglycan Injection, Solution [Package Insert]. American Regent, Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1edcf949-d6de-4921-815d-f86ccf084cae — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1067 (2026-08-01). — Plumb's 10th ed (held) printed p.1040, Polysulfated Glycosaminoglycan monograph spanning p.1039-1040; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 4.4 | IM | Papich Saunders Handbook of Veterinary Drugs, 4th edp.678 | • 4.4 mg/kg IM, twice weekly for up to 4 weeks. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Inhibits catabolic enzymes (metalloproteinases, serine proteases) in cartilage. Stimulates proteoglycan and hyaluronic acid synthesis. Anti-inflammatory in joints.
FDA-approved for dogs and horses. IM injection series (usually 8 doses over 4 weeks). May affect coagulation — avoid in patients on anticoagulants. Injection site reactions.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Polysulfated Glycosaminoglycan dose range in dogs, with cited source references: IM 4.4 mg/kg twice weekly (q3-4d) up to 4 wk, max 8 injections. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Polysulfated Glycosaminoglycan in dogs: IM.
Cited course lengths for Polysulfated Glycosaminoglycan in dogs include: 8-injection series. Duration depends on the indication — match it to the specific dose rule in the table above.
Polysulfated Glycosaminoglycan is indicated in dogs for: Osteoarthritis.
These are general warnings for Polysulfated Glycosaminoglycan across species; consult the dog dosing table above for species-specific guidance. FDA-approved for dogs and horses. IM injection series (usually 8 doses over 4 weeks). May affect coagulation — avoid in patients on anticoagulants. Injection site reactions.
Why a species-specific page? Polysulfated Glycosaminoglycan pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.