ExoticRx · exoticrx.com/drugs/polysulfated-glycosaminoglycan
US brand names:Adequan Canine, Adequan Equine
Polysulfated Glycosaminoglycan is dosed at 4.4 mg/kg IM q3-5 days x 8 injections in dogs, per Adequan Canine- Polysulfated Glycosaminoglycan Injection, Solution [Package Insert]. American Regent, Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1edcf949-d6de-4921-815d-f86ccf084cae — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1067 (2026-08-01).. Verify against current literature before clinical use.
Inhibits catabolic enzymes (metalloproteinases, serine proteases) in cartilage. Stimulates proteoglycan and hyaluronic acid synthesis. Anti-inflammatory in joints.
FDA-approved for dogs and horses. IM injection series (usually 8 doses over 4 weeks). May affect coagulation — avoid in patients on anticoagulants. Injection site reactions.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IM | 4.4 mg/kg | q3-5 days x 8 injections | Strong | Adequan Canine- Polysulfated Glycosaminoglycan Injection, Solution [Package Insert]. American Regent, Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1edcf949-d6de-4921-815d-f86ccf084cae — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1067 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.