ExoticRx · exoticrx.com/drugs/polysulfated-glycosaminoglycan
US brand names:Adequan Canine, Adequan Equine
Polysulfated Glycosaminoglycan is dosed at 2.2 mg/kg SC, IM q3d x 21-28 days, then q14d in rabbits, per Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.879 — Plumb's 10th ed (held) printed p.1040, Polysulfated Glycosaminoglycan monograph spanning p.1039-1040; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — Carpenter's Exotic Animal Formulary 6th ed, Table 10.10 (Miscellaneous Agents Used in Rabbits). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Inhibits catabolic enzymes (metalloproteinases, serine proteases) in cartilage. Stimulates proteoglycan and hyaluronic acid synthesis. Anti-inflammatory in joints.
FDA-approved for dogs and horses. IM injection series (usually 8 doses over 4 weeks). May affect coagulation — avoid in patients on anticoagulants. Injection site reactions.
Species references:All Dog (Domestic) drugsAll Rabbit (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IM | 4.4 mg/kg | twice weekly (q3-4d) up to 4 wk, max 8 injections | Strong | Adequan Canine- Polysulfated Glycosaminoglycan Injection, Solution [Package Insert]. American Regent, Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1edcf949-d6de-4921-815d-f86ccf084cae — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1067 (2026-08-01). — Plumb's 10th ed (held) printed p.1040, Polysulfated Glycosaminoglycan monograph spanning p.1039-1040; page located 2026-08-05 from the book's own running heads, and carries this exact dose under the matching species heading. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.