ExoticRx · exoticrx.com/drugs/polysulfated-glycosaminoglycan
US brand names:Adequan Canine, Adequan Equine
Polysulfated Glycosaminoglycan is dosed at 2.2 mg/kg SC, IM q3d x 21-28 days, then q14d in rabbits, per Plumb's Veterinary Drug Handbook, 10th ed (2023) — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.879 — Plumb's 10th ed printed p.1040, Polysulfated Glycosaminoglycan monograph spanning p.1039-1040. — Carpenter's Exotic Animal Formulary 6th ed, Table 10.10 (Miscellaneous Agents Used in Rabbits). Verify against current literature before clinical use.
Inhibits catabolic enzymes (metalloproteinases, serine proteases) in cartilage. Stimulates proteoglycan and hyaluronic acid synthesis. Anti-inflammatory in joints.
FDA-approved for dogs and horses. IM injection series (usually 8 doses over 4 weeks). May affect coagulation — avoid in patients on anticoagulants. Injection site reactions.
Species references:All Dog (Domestic) drugsAll Rabbit (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | IM | 4.4 mg/kg | twice weekly (q3-4d) up to 4 wk, max 8 injections | Strong | Adequan Canine- Polysulfated Glycosaminoglycan Injection, Solution [Package Insert]. American Regent, Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1edcf949-d6de-4921-815d-f86ccf084cae — Plumb's 10th ed printed p.1040, Polysulfated Glycosaminoglycan monograph spanning p.1039-1040. |
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