ExoticRx · exoticrx.com/drugs/pioglitazone
Actos
PPARgamma agonist that improves insulin sensitivity in peripheral tissues by enhancing adipocyte differentiation and glucose transporter expression.
Hepatotoxicity risk — monitor liver enzymes. Weight gain and fluid retention. Limited veterinary use — investigational for insulin-resistant diabetic cats.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5–3 mg/kg | q24h | Weak | Veterinary Endocrinology Literature Review |
| Cat (Domestic) | PO | 0.5–2 mg/kg | q24h | Extrapolated | Veterinary Endocrinology Literature Review |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.