Cat · Felis catus · typical adult weight 2.50–7.00 kg
Pioglitazone is dosed at 0.5–2 mg/kg PO q24h in cats, per Corroborated 2026-07-31: Clark M et al. J Vet Intern Med 2014;28(1):166-174. doi:10.1111/jvim.12255 PMID:24592408 - cat, pioglitazone 1 or 3 mg/kg PO q24h for 7 wk in obese non-diabetic cats; insulin sensitivity improved only at 3 mg/kg.. Pioglitazone is used in cats for Insulin-resistant diabetes. Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Pioglitazone in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Actos
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.5–2 mg/kg | q24h | Investigational; monitor liver enzymes | Insulin-resistant diabetes | Extrapolated | Corroborated 2026-07-31: Clark M et al. J Vet Intern Med 2014;28(1):166-174. doi:10.1111/jvim.12255 PMID:24592408 - cat, pioglitazone 1 or 3 mg/kg PO q24h for 7 wk in obese non-diabetic cats; insulin sensitivity improved only at 3 mg/kg. |
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These ranges are per kg. Enter your cat's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
PPARgamma agonist that improves insulin sensitivity in peripheral tissues by enhancing adipocyte differentiation and glucose transporter expression.
Hepatotoxicity risk — monitor liver enzymes. Weight gain and fluid retention. Limited veterinary use — investigational for insulin-resistant diabetic cats.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Pioglitazone dose range in cats, with cited source references: PO 0.5–2 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Pioglitazone in cats: PO.
Cited course lengths for Pioglitazone in cats include: Investigational; monitor liver enzymes. Duration depends on the indication — match it to the specific dose rule in the table above.
Pioglitazone is indicated in cats for: Insulin-resistant diabetes.
These are general warnings for Pioglitazone across species; consult the cat dosing table above for species-specific guidance. Hepatotoxicity risk — monitor liver enzymes. Weight gain and fluid retention. Limited veterinary use — investigational for insulin-resistant diabetic cats.
Why a species-specific page? Pioglitazone pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.