Pocket Pet · Oryctolagus cuniculus · typical adult weight 1.00–5.00 kg
Piperazine is dosed at 100–200 mg/kg PO once, repeat in 14 days in rabbits, per Quesenberry K, Orcutt C, Mans C, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Chapter 14 'Gastrointestinal Diseases of Rabbits', p.185 (doi:10.1016/B978-0-323-48435-0.00014-9) | Carpenter's rabbit rows cite: 194. Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) ed. — Verified against Quesenberry et al., Ferrets, Rabbits and Rodents, 4th Ed, p.197 (2026-08-01). — Plumb's 10th ed (held) printed p.1031, Piperazine monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929; Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery — ISBN 9780323484350, https://openlibrary.org/isbn/9780323484350. Piperazine is used in rabbits for Pinworms (Passalurus ambiguus). Routes documented in rabbits: PO. A typical adult rabbit weighs 1.00–5.00 kg. ExoticRx lists 1 cited dose rule for Piperazine in rabbits, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Pipa-Tabs, Sergeants Worm Away
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 100–200 mg/kg | once, repeat in 14 days | 2 doses | Pinworms (Passalurus ambiguus) | Moderate | Quesenberry K, Orcutt C, Mans C, Carpenter JW, eds. Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery, 4th ed., Chapter 14 'Gastrointestinal Diseases of Rabbits', p.185 (doi:10.1016/B978-0-323-48435-0.00014-9) | Carpenter's rabbit rows cite: 194. Plumb's Veterinary Drug Handbook, 10th ed (2023, held copy; the original seed cited the 9th, which was never consulted) ed. — Verified against Quesenberry et al., Ferrets, Rabbits and Rodents, 4th Ed, p.197 (2026-08-01). — Plumb's 10th ed (held) printed p.1031, Piperazine monograph; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929; Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery — ISBN 9780323484350, https://openlibrary.org/isbn/9780323484350 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 200 | PO | BSAVA Small Animal Formulary, 10th ed — Part B (Exotic Pets)p.255 | 200 mg/kg p.o., repeat in 2-3 weeks |
| 100 | PO | Carpenter's Exotic Animal Formulary, 6th edTable 10.3 | 100 mg/kg PO q24h × 2 days |
| 200–500 | PO | Carpenter's Exotic Animal Formulary, 6th edTable 10.3 | 200-500 mg/kg PO × 2 days |
| 750 | PO | Carpenter's Exotic Animal Formulary, 6th ed |
Need the exact dose for your patient?
These ranges are per kg. Enter your rabbit's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
GABA agonist that causes flaccid paralysis in ascarids (roundworms). Worms are expelled alive by peristalsis.
Only effective against ascarids (roundworms). Wide safety margin. May cause vomiting at high doses. Do not combine with pyrantel (antagonistic).
Species-specific contraindications and adverse-reaction reports for rabbits may differ from canine / feline reference data — consult the primary citations listed with each rule.
Piperazine dose range in rabbits, with cited source references: PO 100–200 mg/kg once, repeat in 14 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Piperazine in rabbits: PO.
Cited course lengths for Piperazine in rabbits include: 2 doses. Duration depends on the indication — match it to the specific dose rule in the table above.
Piperazine is indicated in rabbits for: Pinworms (Passalurus ambiguus).
These are general warnings for Piperazine across species; consult the rabbit dosing table above for species-specific guidance. Only effective against ascarids (roundworms). Wide safety margin. May cause vomiting at high doses. Do not combine with pyrantel (antagonistic).
Why a species-specific page? Piperazine pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in rabbits — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 750 mg/kg PO × 2 days |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.