Question 1

What is Piperazine used for?

Accepted Answer

Piperazine is indicated for: Roundworm (Toxocara), Roundworm infections.

Question 2

What routes can Piperazine be administered by?

Accepted Answer

Available routes: PO.

Question 3

Which species have cited Piperazine dosing data?

Accepted Answer

Piperazine dosing in the ExoticRx formulary covers 5 species: African Grey Parrot, Cat (Domestic), Dog (Domestic), Guinea Pig, Rabbit (Domestic).

Question 4

Is Piperazine a controlled substance?

Accepted Answer

Piperazine is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Piperazine?

Accepted Answer

Only effective against ascarids (roundworms). Wide safety margin. May cause vomiting at high doses. Do not combine with pyrantel (antagonistic).

Question 6

What are the side effects of Piperazine?

Accepted Answer

Reported side effects, adverse reactions, and contraindications for Piperazine: Only effective against ascarids (roundworms). Wide safety margin. May cause vomiting at high doses. Do not combine with pyrantel (antagonistic).

Question 7

How does Piperazine work?

Accepted Answer

GABA agonist that causes flaccid paralysis in ascarids (roundworms). Worms are expelled alive by peristalsis.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	44–66 mg/kg	once, repeat in 14-21 days	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	44–66 mg/kg	once, repeat in 14-21 days	Moderate	Plumb's Veterinary Drug Handbook, 9th Ed

Piperazine

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Piperazine dosing data (5 dose rules)

Evidence levels across 5 dose rules

Backed by 2 published sources

Sample dosing (2 of 5 cited rules)

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