Equine · Equus caballus · typical adult weight 350.00–700.00 kg
Ponazuril (Livestock) is dosed at 5–10 mg/kg PO q24h in horses, per US FDA. MARQUIS 15% Antiprotozoal Oral Paste (ponazuril), NADA 141-188, Boehringer Ingelheim. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=888b1dde-fc9b-4022-b24b-7162da32e4e2 - horses only; 15 mg/kg PO loading dose on Day 1, then 5 mg/kg PO q24h for 27 more days.. Ponazuril (Livestock) is used in horses for EPM (Sarcocystis neurona), Equine protozoal myeloencephalitis (EPM). Routes documented in horses: PO. A typical adult horse weighs 350.00–700.00 kg. ExoticRx lists 2 cited dose rules for Ponazuril (Livestock) in horses, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Toltrazuril Sulfone
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–10 mg/kg | q24h | 28 days | EPM (Sarcocystis neurona) | Strong | US FDA. MARQUIS 15% Antiprotozoal Oral Paste (ponazuril), NADA 141-188, Boehringer Ingelheim. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=888b1dde-fc9b-4022-b24b-7162da32e4e2 - horses only; 15 mg/kg PO loading dose on Day 1, then 5 mg/kg PO q24h for 27 more days. |
| PO | 5–10 mg/kg | q24h | 28 days | Equine protozoal myeloencephalitis (EPM) | Strong | US FDA. Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste, NADA 141-188, Boehringer Ingelheim. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=888b1dde-fc9b-4022-b24b-7162da32e4e2 - horses; 15 mg/kg PO loading dose day 1, then 5 mg/kg PO once daily days 2-28. |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.680 | • Treatment of EPM: 5 mg/kg q24h PO for 28 days. A loading dose of 15 mg/kg |
| 15 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.680 | • Treatment of EPM: 5 mg/kg q24h PO for 28 days. A loading dose of 15 mg/kg |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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Active metabolite of toltrazuril. Inhibits mitochondrial enzyme systems in coccidia, disrupting nuclear division and mitochondrial function in all intracellular stages.
Extra-label use in livestock. Primarily used in calves and lambs for coccidiosis treatment and prevention. Long half-life allows single-dose protocols.
Species-specific contraindications and adverse-reaction reports for horses may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ponazuril (Livestock) dose ranges in horses, with cited source references: PO 5–10 mg/kg q24h; PO 5–10 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ponazuril (Livestock) in horses: PO.
Cited course lengths for Ponazuril (Livestock) in horses include: 28 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Ponazuril (Livestock) is indicated in horses for: EPM (Sarcocystis neurona), Equine protozoal myeloencephalitis (EPM).
These are general warnings for Ponazuril (Livestock) across species; consult the horse dosing table above for species-specific guidance. Extra-label use in livestock. Primarily used in calves and lambs for coccidiosis treatment and prevention. Long half-life allows single-dose protocols.
Why a species-specific page? Ponazuril (Livestock) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in horses — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.