Equine · Equus caballus · typical adult weight 350.00–700.00 kg
Ponazuril (Livestock) is dosed at 5–10 mg/kg PO q24h in horses, per US FDA. Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste, NADA 141-188, Boehringer Ingelheim. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=888b1dde-fc9b-4022-b24b-7162da32e4e2 - horses; 15 mg/kg PO loading dose day 1, then 5 mg/kg PO once daily days 2-28.. Ponazuril (Livestock) is used in horses for Equine protozoal myeloencephalitis (EPM), EPM (Sarcocystis neurona). Routes documented in horses: PO. A typical adult horse weighs 350.00–700.00 kg. ExoticRx lists 2 cited dose rules for Ponazuril (Livestock) in horses, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Toltrazuril Sulfone
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–10 mg/kg | q24h | 28 days | Equine protozoal myeloencephalitis (EPM) | Strong | US FDA. Marquis (15% w/w ponazuril) Antiprotozoal Oral Paste, NADA 141-188, Boehringer Ingelheim. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=888b1dde-fc9b-4022-b24b-7162da32e4e2 - horses; 15 mg/kg PO loading dose day 1, then 5 mg/kg PO once daily days 2-28. |
| PO | 5–10 mg/kg | q24h | 28 days | EPM (Sarcocystis neurona) | Strong | US FDA. MARQUIS 15% Antiprotozoal Oral Paste (ponazuril), NADA 141-188, Boehringer Ingelheim. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=888b1dde-fc9b-4022-b24b-7162da32e4e2 - horses only; 15 mg/kg PO loading dose on Day 1, then 5 mg/kg PO q24h for 27 more days. |
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Active metabolite of toltrazuril. Inhibits mitochondrial enzyme systems in coccidia, disrupting nuclear division and mitochondrial function in all intracellular stages.
Extra-label use in livestock. Primarily used in calves and lambs for coccidiosis treatment and prevention. Long half-life allows single-dose protocols.
Species-specific contraindications and adverse-reaction reports for horses may differ from canine / feline reference data — consult the primary citations listed with each rule.
Ponazuril (Livestock) dose ranges in horses, with cited source references: PO 5–10 mg/kg q24h; PO 5–10 mg/kg q24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Ponazuril (Livestock) in horses: PO.
Cited course lengths for Ponazuril (Livestock) in horses include: 28 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Ponazuril (Livestock) is indicated in horses for: Equine protozoal myeloencephalitis (EPM), EPM (Sarcocystis neurona).
These are general warnings for Ponazuril (Livestock) across species; consult the horse dosing table above for species-specific guidance. Extra-label use in livestock. Primarily used in calves and lambs for coccidiosis treatment and prevention. Long half-life allows single-dose protocols.
Why a species-specific page? Ponazuril (Livestock) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in horses — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.