Equine · Equus caballus · typical adult weight 350.00–700.00 kg
Moxidectin is dosed at 0.4 mg/kg PO single dose in horses, per QUEST - Moxidectin Gel [US Product Label for Horses]. Zoetis Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=362ddd91-a63f-4ec6-841a-75785dd208c8 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.943 (2026-08-01). — Plumb's 10th ed (held) printed p.912, Moxidectin/Moxidectin Combination Products monograph spanning p.912-917; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Moxidectin is used in horses for GI strongyles, bots, encysted cyathostomins, Strongyles, bots, encysted cyathostomes. Routes documented in horses: PO. A typical adult horse weighs 350.00–700.00 kg. ExoticRx lists 2 cited dose rules for Moxidectin in horses, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: ProHeart, Advantage Multi, ProHeart 6, ProHeart 12
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.4 mg/kg | single dose | — | GI strongyles, bots, encysted cyathostomins | Strong | QUEST - Moxidectin Gel [US Product Label for Horses]. Zoetis Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=362ddd91-a63f-4ec6-841a-75785dd208c8 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.943 (2026-08-01). — Plumb's 10th ed (held) printed p.912, Moxidectin/Moxidectin Combination Products monograph spanning p.912-917; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
| PO | 0.4 mg/kg | Once | Single dose | Strongyles, bots, encysted cyathostomes | Strong | QUEST PLUS - Moxidectin/Praziquantel Gel [US Product Label for Horses]. Zoetis Inc; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5ebc9173-18cf-425e-8e37-69a1715bd9af — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.943 (2026-08-01). — Plumb's 10th ed (held) printed p.912, Moxidectin/Moxidectin Combination Products monograph spanning p.912-917; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.4 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.576 | • Gastrointestinal parasites: 0.4 mg/kg PO. Avoid use in young horses, small |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your horse's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Binds glutamate-gated chloride channels in invertebrate nerve/muscle cells. Sustained-release formulation provides 6- or 12-month heartworm prevention.
Caution in MDR1-mutant dogs. ProHeart injection: risk of anaphylaxis (monitor 30 min post-injection). Test for heartworm before starting. Store properly.
Species-specific contraindications and adverse-reaction reports for horses may differ from canine / feline reference data — consult the primary citations listed with each rule.
Moxidectin dose ranges in horses, with cited source references: PO 0.4 mg/kg single dose; PO 0.4 mg/kg Once. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Moxidectin in horses: PO.
Cited course lengths for Moxidectin in horses include: Single dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Moxidectin is indicated in horses for: GI strongyles, bots, encysted cyathostomins, Strongyles, bots, encysted cyathostomes.
These are general warnings for Moxidectin across species; consult the horse dosing table above for species-specific guidance. Caution in MDR1-mutant dogs. ProHeart injection: risk of anaphylaxis (monitor 30 min post-injection). Test for heartworm before starting. Store properly.
Why a species-specific page? Moxidectin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in horses — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.