Equine · Equus caballus · typical adult weight 350.00–700.00 kg
Moxidectin is dosed at 0.4 mg/kg PO single dose in horses, per QUEST - Moxidectin Gel [US Product Label for Horses]. Zoetis Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=362ddd91-a63f-4ec6-841a-75785dd208c8 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.943 (2026-08-01).. Moxidectin is used in horses for GI strongyles, bots, encysted cyathostomins, Strongyles, bots, encysted cyathostomes. Routes documented in horses: PO. A typical adult horse weighs 350.00–700.00 kg. ExoticRx lists 2 cited dose rules for Moxidectin in horses, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: ProHeart, Advantage Multi, ProHeart 6, ProHeart 12
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.4 mg/kg | single dose | — | GI strongyles, bots, encysted cyathostomins | Strong | QUEST - Moxidectin Gel [US Product Label for Horses]. Zoetis Inc.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=362ddd91-a63f-4ec6-841a-75785dd208c8 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.943 (2026-08-01). |
| PO | 0.4 mg/kg | Once | Single dose | Strongyles, bots, encysted cyathostomes | Strong | QUEST PLUS - Moxidectin/Praziquantel Gel [US Product Label for Horses]. Zoetis Inc; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=5ebc9173-18cf-425e-8e37-69a1715bd9af — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.943 (2026-08-01). |
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These ranges are per kg. Enter your horse's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Binds glutamate-gated chloride channels in invertebrate nerve/muscle cells. Sustained-release formulation provides 6- or 12-month heartworm prevention.
Caution in MDR1-mutant dogs. ProHeart injection: risk of anaphylaxis (monitor 30 min post-injection). Test for heartworm before starting. Store properly.
Species-specific contraindications and adverse-reaction reports for horses may differ from canine / feline reference data — consult the primary citations listed with each rule.
Moxidectin dose ranges in horses, with cited source references: PO 0.4 mg/kg single dose; PO 0.4 mg/kg Once. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Moxidectin in horses: PO.
Cited course lengths for Moxidectin in horses include: Single dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Moxidectin is indicated in horses for: GI strongyles, bots, encysted cyathostomins, Strongyles, bots, encysted cyathostomes.
These are general warnings for Moxidectin across species; consult the horse dosing table above for species-specific guidance. Caution in MDR1-mutant dogs. ProHeart injection: risk of anaphylaxis (monitor 30 min post-injection). Test for heartworm before starting. Store properly.
Why a species-specific page? Moxidectin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in horses — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.