Livestock · Ovis aries · typical adult weight 30.00–120.00 kg
Moxidectin is dosed at 0.2 mg/kg PO single dose in sheep, per CYDECTIN ORAL DRENCH FOR SHEEP - Moxidectin Liquid [US Product Label]. Elanco US Inc.; 2020. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.943 (2026-08-01).. Moxidectin is used in sheep for GI nematodes, GI nematodes including resistant Haemonchus. Routes documented in sheep: PO. A typical adult sheep weighs 30.00–120.00 kg. ExoticRx lists 2 cited dose rules for Moxidectin in sheep, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: ProHeart, Advantage Multi, ProHeart 6, ProHeart 12
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 0.2 mg/kg | single dose | — | GI nematodes | Moderate | CYDECTIN ORAL DRENCH FOR SHEEP - Moxidectin Liquid [US Product Label]. Elanco US Inc.; 2020. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.943 (2026-08-01). |
| PO | 0.2 mg/kg | Once | Single dose | GI nematodes including resistant Haemonchus | Strong | CYDECTIN ORAL DRENCH FOR SHEEP - Moxidectin Liquid [US Product Label]. Elanco US Inc.; 2020. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.943 (2026-08-01). |
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These ranges are per kg. Enter your sheep's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Binds glutamate-gated chloride channels in invertebrate nerve/muscle cells. Sustained-release formulation provides 6- or 12-month heartworm prevention.
Caution in MDR1-mutant dogs. ProHeart injection: risk of anaphylaxis (monitor 30 min post-injection). Test for heartworm before starting. Store properly.
Species-specific contraindications and adverse-reaction reports for sheep may differ from canine / feline reference data — consult the primary citations listed with each rule.
Moxidectin dose ranges in sheep, with cited source references: PO 0.2 mg/kg single dose; PO 0.2 mg/kg Once. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Moxidectin in sheep: PO.
Cited course lengths for Moxidectin in sheep include: Single dose. Duration depends on the indication — match it to the specific dose rule in the table above.
Moxidectin is indicated in sheep for: GI nematodes, GI nematodes including resistant Haemonchus.
These are general warnings for Moxidectin across species; consult the sheep dosing table above for species-specific guidance. Caution in MDR1-mutant dogs. ProHeart injection: risk of anaphylaxis (monitor 30 min post-injection). Test for heartworm before starting. Store properly.
Why a species-specific page? Moxidectin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in sheep — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.