Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.
Moxidectin is dosed at 0.2 mg/kg PO repeat in 10 days in rabbits, per Plumb's Veterinary Drug Handbook, 10th ed (2023) | Wagner R, Wendlberger U. Field efficacy of moxidectin in dogs and rabbits naturally infested with Sarcoptes spp., Demodex spp., and Psoroptes spp. mites. Vet Parasitol. 2000;93:149-158. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.851 — Plumb's 10th ed printed p.912, Moxidectin/Moxidectin Combination Products monograph spanning p.912-917. — Carpenter's Exotic Animal Formulary 6th ed, Table 10.3 (Antiparasitic Agents Used in Rabbits.a). — CITATION COMPONENT WITHDRAWN AS UNSUPPORTIVE: the Plumb 10th ed component does not carry this rule. The Moxidectin/Moxidectin Combination Products monograph, printed p.912-917, prints species dosage headings CATS, CATTLE, DOGS, FERRETS, GOATS, HORSES and SHEEP only - the strings rabbit, lagomorph and Oryctolagus do not occur anywhere in it, and its single Psoroptes mention at printed p.913 is "Mites: Chorioptes bovis, Psoroptes ovis" under a food-animal heading. Carpenter ref 194 is the NINTH edition, so the held 10th is an edition substitution as well. THE RULE IS NOT UNSOURCED: Carpenter 6th ed Table 10.3 (Antiparasitic Agents Used in Rabbits) prints "Moxidectin 0.2 mg/kg PO, repeat in 10 days194,243 | Psoroptic mange", and ref 243 = Wagner R, Wendlberger U, Vet Parasitol 2000, 93:149-158, a rabbit Psoroptes field-efficacy paper whose abstract prints "Seven rabbits were treated orally with 0.2mg/kg moxidectin twice 10 days apart" (n=7, abstract only, full text not read). The BOUNDED TWO-DOSE COURSE must not render as an indefinite 10-day cycle. Verify against current literature before clinical use.
Binds glutamate-gated chloride channels in invertebrate nerve/muscle cells. Sustained-release formulation provides 6- or 12-month heartworm prevention.
Side effects & warnings
Caution in MDR1-mutant dogs. ProHeart injection: risk of anaphylaxis (monitor 30 min post-injection). Test for heartworm before starting. Store properly.
Species with Moxidectin dosing data (20 dose rules)
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
Sample dosing (1 of 20 cited rules)
A dog/cat sample is shown here. Cited dosing for all 17 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
Plumb's Veterinary Drug Handbook, 10th ed. (2023), printed p.915, DOGS / ProHeart 6 and ProHeart 12 label dosage (FDA-approved). — Plumb's Veterinary Drug Handbook, 10th ed, Moxidectin monograph, printed p.915, DOGS: "Moxidectin 10% (ProHeart 6 or ProHeart 12) labeled indications (label dosage; FDA-approved): 0.05 […]"Compilation only — we have not located an independent source that prints this figure.
· 128. Mook DM, Benjamin KA. Use of selamectin and moxidectin in the treatment of mouse fur mites. J Am Assoc Lab Anim Sci. 2008;47:20-24. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.778 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.2 (Antiparasitic Agents Used in Rodents).
· 55. Pantchev N, Hofmann T. Notoedric mange caused by Notoedres cati in a pet African pygmy hedgehog (Atelerix albiventris). Vet Rec. 2006;158:59-60. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.738 — Carpenter's Exotic Animal Formulary 6th ed, Table 8.3 (Antiparasitic Agents Used in Hedgehogs).
· CYDECTIN INJECTION FOR BEEF AND NONLACTATING DAIRY CATTLE - Moxidectin Injection, Solution [US Product Label]. Elanco US Inc.; 2020. — Plumb's 10th ed printed p.916, Moxidectin/Moxidectin Combination Products monograph spanning p.912-917.
· CYDECTIN ORAL DRENCH FOR SHEEP - Moxidectin Liquid [US Product Label]. Elanco US Inc.; 2020. — Plumb's 10th ed printed p.916, Moxidectin/Moxidectin Combination Products monograph spanning p.912-917.
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CYDECTIN ORAL DRENCH FOR SHEEP - Moxidectin Liquid [US Product Label]. Elanco US Inc.; 2020.; Snyder J. Management of internal parasites in sheep I & II. Presented at: WVC; 2009. PMID: 5689174 — Plumb's 10th ed printed p.912, Moxidectin/Moxidectin Combination Products monograph spanning p.912-917.
· Plumb's Veterinary Drug Handbook, 10th ed (2023) | Wagner R, Wendlberger U. Field efficacy of moxidectin in dogs and rabbits naturally infested with Sarcoptes spp., Demodex spp., and Psoroptes spp. mites. Vet Parasitol. 2000;93:149-158. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.851 — Plumb's 10th ed printed p.912, Moxidectin/Moxidectin Combination Products monograph spanning p.912-917. — Carpenter's Exotic Animal Formulary 6th ed, Table 10.3 (Antiparasitic Agents Used in Rabbits.a). — CITATION COMPONENT WITHDRAWN AS UNSUPPORTIVE: the Plumb 10th ed component does not carry this rule. The Moxidectin/Moxidectin Combination Products monograph, printed p.912-917, prints species dosage headings CATS, CATTLE, DOGS, FERRETS, GOATS, HORSES and SHEEP only - the strings rabbit, lagomorph and Oryctolagus do not occur anywhere in it, and its single Psoroptes mention at printed p.913 is "Mites: Chorioptes bovis, Psoroptes ovis" under a food-animal heading. Carpenter ref 194 is the NINTH edition, so the held 10th is an edition substitution as well. THE RULE IS NOT UNSOURCED: Carpenter 6th ed Table 10.3 (Antiparasitic Agents Used in Rabbits) prints "Moxidectin 0.2 mg/kg PO, repeat in 10 days194,243 | Psoroptic mange", and ref 243 = Wagner R, Wendlberger U, Vet Parasitol 2000, 93:149-158, a rabbit Psoroptes field-efficacy paper whose abstract prints "Seven rabbits were treated orally with 0.2mg/kg moxidectin twice 10 days apart" (n=7, abstract only, full text not read). The BOUNDED TWO-DOSE COURSE must not render as an indefinite 10-day cycle.
· Ramsey I, ed. BSAVA Small Animal Formulary, 10th ed. Part B: Exotic Pets. Gloucester: British Small Animal Veterinary Association; 2023. p.211.
· Samour, Avian Medicine, 3rd Ed. (raptor formulary appendix), p.667. Row as printed binds this dose to raptors on its own line: "Moxidectin Imox tablets 1000 mg/ Raptors PO 0.5 to 1 mg/kg once For the treatment of internal and external parasites".