Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Moxidectin is dosed at 0.17 mg/kg SC q6 months (ProHeart 6) in dogs, per Plumb's Veterinary Drug Handbook, 10th ed. (2023), printed p.915 (corpus PDF p.942), DOGS / ProHeart 6 and ProHeart 12 label dosage (FDA-approved). — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — Plumb's Veterinary Drug Handbook, 10th ed (held), Moxidectin monograph, printed p.915 (corpus PDF p.942), DOGS: "Moxidectin 10% (ProHeart 6 or ProHeart 12) labeled indications (label dosage; FDA-approved): 0.05 […]" [SCOPE NARROWED 2026-08-12 — this row serves the ProHeart 6 figure only; the ProHeart 12 figure is 0.5 mg/kg.]. Moxidectin is used in dogs for Heartworm prevention and hookworm treatment (ProHeart 6, 6-month injection). Routes documented in dogs: SC. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Moxidectin in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: ProHeart, Advantage Multi, ProHeart 6, ProHeart 12
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| SC | 0.17 mg/kg | q6 months (ProHeart 6) | 6-month injection (ProHeart 6) | Heartworm prevention and hookworm treatment (ProHeart 6, 6-month injection) | Strong | Plumb's Veterinary Drug Handbook, 10th ed. (2023), printed p.915 (corpus PDF p.942), DOGS / ProHeart 6 and ProHeart 12 label dosage (FDA-approved). — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 — Plumb's Veterinary Drug Handbook, 10th ed (held), Moxidectin monograph, printed p.915 (corpus PDF p.942), DOGS: "Moxidectin 10% (ProHeart 6 or ProHeart 12) labeled indications (label dosage; FDA-approved): 0.05 […]" [SCOPE NARROWED 2026-08-12 — this row serves the ProHeart 6 figure only; the ProHeart 12 figure is 0.5 mg/kg.] |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mcg/kg) | Route | Source | As printed |
|---|---|---|---|
| 500 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.576 | Demodex cases, with doses of 500 mcg/kg (0.5 mg/kg)/day PO for 21-23 weeks |
| 3 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.576 | • Heartworm prevention: 3 mcg/kg every 30 days PO. Topical heartworm preven- |
| 170 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.576 | • Heartworm prevention (long-acting injectable): 0.17 mg/kg (170 mcg/kg) SQ |
| 25–300 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.576 | • Endoparasite control: 25-300 mcg/kg. |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Binds glutamate-gated chloride channels in invertebrate nerve/muscle cells. Sustained-release formulation provides 6- or 12-month heartworm prevention.
Caution in MDR1-mutant dogs. ProHeart injection: risk of anaphylaxis (monitor 30 min post-injection). Test for heartworm before starting. Store properly.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Moxidectin dose range in dogs, with cited source references: SC 0.17 mg/kg q6 months (ProHeart 6). Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Moxidectin in dogs: SC.
Cited course lengths for Moxidectin in dogs include: 6-month injection (ProHeart 6). Duration depends on the indication — match it to the specific dose rule in the table above.
Moxidectin is indicated in dogs for: Heartworm prevention and hookworm treatment (ProHeart 6, 6-month injection).
These are general warnings for Moxidectin across species; consult the dog dosing table above for species-specific guidance. Caution in MDR1-mutant dogs. ProHeart injection: risk of anaphylaxis (monitor 30 min post-injection). Test for heartworm before starting. Store properly.
Why a species-specific page? Moxidectin pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 200–250 |
| PO |
| Papich Saunders Handbook of Veterinary Drugs, 4th edp.576 |
| • Sarcoptic mange: 200-250 mcg/kg (0.2-0.25 mg/kg) PO or SQ once per week |
| 200 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.576 | • Demodicosis: 200 mcg/kg SQ weekly or every other week for 1-4 doses; alterna- |
| 400 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.576 | tively, higher doses of 400 mcg/kg/day PO. Higher doses are used for refractory |
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2.5 | IM | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.293 | • Parasites (many): 2.5 mg/kg moxidectin. Apply once every month. Minimum dose recommendation 0.1 ml/kg. • Demodico |
| 2.5 | — | Papich Saunders Handbook of Veterinary Drugs, 4th edp.576 | tion (Advantage Multi) 2.5mg/kg monthly. |
| 0.17 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.576 | • Heartworm prevention (long-acting injectable): 0.17 mg/kg (170 mcg/kg) SQ |
| 0.2–0.25 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.576 | • Sarcoptic mange: 200-250 mcg/kg (0.2-0.25 mg/kg) PO or SQ once per week |
| 0.5 | PO | Papich Saunders Handbook of Veterinary Drugs, 4th edp.576 | Demodex cases, with doses of 500 mcg/kg (0.5 mg/kg)/day PO for 21-23 weeks |
| 0.5–1 | SC | Papich Saunders Handbook of Veterinary Drugs, 4th edp.576 | or 0.5-1.0 mg/kg SQ q72h for 21-22 weeks. Duration of treatment for demodi- |
| Dose (ml/kg) | Route | Source | As printed |
|---|---|---|---|
| 0.1 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.293 | tin. Apply once every month. Minimum dose recommendation 0.1 ml/kg. • Demodicosis (severe): apply product weekly |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.