ExoticRx · exoticrx.com/drugs/pretomanid
US brand names:PA-824
Pretomanid is dosed at 3–6 mg/kg PO q24h in cats, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Prodrug activated by mycobacterial nitroreductase. Inhibits mycolic acid synthesis and generates reactive nitrogen species under anaerobic conditions.
Hepatotoxicity. Used in combination with bedaquiline and linezolid (BPaL regimen). No veterinary data.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.