Cat · Felis catus · typical adult weight 2.50–7.00 kg
Propylthiouracil is dosed at 50 mg per cat PO q12h in cats, per Plumb's Veterinary Drug Handbook, 9th Ed. Propylthiouracil is used in cats for Feline hyperthyroidism (historical use). Routes documented in cats: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Propylthiouracil in cats, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: PTU
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 50 mg per catmax 100 mg total | q12h | NOT RECOMMENDED — use methimazole instead | Feline hyperthyroidism (historical use) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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Inhibits thyroid peroxidase-mediated iodination and coupling reactions, and at high doses inhibits peripheral T4 to T3 conversion.
Higher hepatotoxicity and immune-mediated reactions than methimazole. Not recommended in cats — methimazole preferred. Monitor CBC and liver function.
Species-specific contraindications and adverse-reaction reports for cats may differ from canine / feline reference data — consult the primary citations listed with each rule.
Propylthiouracil dose range in cats, with cited source references: PO 50 mg per cat q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Propylthiouracil in cats: PO.
Cited course lengths for Propylthiouracil in cats include: NOT RECOMMENDED — use methimazole instead. Duration depends on the indication — match it to the specific dose rule in the table above.
Propylthiouracil is indicated in cats for: Feline hyperthyroidism (historical use).
These are general warnings for Propylthiouracil across species; consult the cat dosing table above for species-specific guidance. Higher hepatotoxicity and immune-mediated reactions than methimazole. Not recommended in cats — methimazole preferred. Monitor CBC and liver function.
Why a species-specific page? Propylthiouracil pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cats — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.