Cat · Felis catus · typical adult weight 2.50–7.00 kg
Propylthiouracil is used in cat for Feline hyperthyroidism (historical use). Routes documented in cat: PO. A typical adult cat weighs 2.50–7.00 kg. ExoticRx lists 1 cited dose rule for Propylthiouracil in cat, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: PTU
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 50 mg per cat | q12h | NOT RECOMMENDED — use methimazole instead | Feline hyperthyroidism (historical use) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
Absolute dose ceiling, regardless of body weight: 100 mg total (PO).
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Inhibits thyroid peroxidase-mediated iodination and coupling reactions, and at high doses inhibits peripheral T4 to T3 conversion.
Higher hepatotoxicity and immune-mediated reactions than methimazole. Not recommended in cats — methimazole preferred. Monitor CBC and liver function.
Species-specific contraindications and adverse-reaction reports for cat may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Propylthiouracil pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cat — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.