Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Prostaglandin F2-alpha is dosed at 0.025–0.25 mg/kg SC q12-24h in dogs, per Smith FO. Pyometra. In: Bonagura JD, Twedt DC, eds. Kirk's Current Veterinary Therapy XV. Saunders Elsevier; 2014:967-969. / 10. Feldman E. The cystic endometrial hyperplasia/pyometra complex and infertility in female dogs. In: Ettinger S, Feldman E, eds. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.434 (2026-08-01).. Prostaglandin F2-alpha is used in dogs for Open pyometra. Routes documented in dogs: SC. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Prostaglandin F2-alpha in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Lutalyse
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| SC | 0.025–0.25 mg/kg | q12-24h | 3-7 days, titrate up | Open pyometra | Moderate | Smith FO. Pyometra. In: Bonagura JD, Twedt DC, eds. Kirk's Current Veterinary Therapy XV. Saunders Elsevier; 2014:967-969. / 10. Feldman E. The cystic endometrial hyperplasia/pyometra complex and infertility in female dogs. In: Ettinger S, Feldman E, eds. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.434 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Causes luteolysis, myometrial contraction, and smooth muscle contraction. Used for estrus synchronization, pregnancy termination, and pyometra treatment.
Causes panting, salivation, vomiting, diarrhea, abdominal pain in small animals. Abortifacient — handle with gloves. Bronchoconstriction in asthmatics.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Prostaglandin F2-alpha dose range in dogs, with cited source references: SC 0.025–0.25 mg/kg q12-24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Prostaglandin F2-alpha in dogs: SC.
Cited course lengths for Prostaglandin F2-alpha in dogs include: 3-7 days, titrate up. Duration depends on the indication — match it to the specific dose rule in the table above.
Prostaglandin F2-alpha is indicated in dogs for: Open pyometra.
These are general warnings for Prostaglandin F2-alpha across species; consult the dog dosing table above for species-specific guidance. Causes panting, salivation, vomiting, diarrhea, abdominal pain in small animals. Abortifacient — handle with gloves. Bronchoconstriction in asthmatics.
Why a species-specific page? Prostaglandin F2-alpha pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.