ExoticRx · exoticrx.com/drugs/prostaglandin-f2-alpha
US brand names:Lutalyse(dinoprost tromethamine)
Prostaglandin F2-alpha is dosed at 0.025–0.25 mg/kg SC q12-24h in dogs, per Smith FO. Pyometra. In: Bonagura JD, Twedt DC, eds. Kirk's Current Veterinary Therapy XV. Saunders Elsevier; 2014:967-969. / 10. Feldman E. The cystic endometrial hyperplasia/pyometra complex and infertility in female dogs. In: Ettinger S, Feldman E, eds. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.434 (2026-08-01).. Verify against current literature before clinical use.
Causes luteolysis, myometrial contraction, and smooth muscle contraction. Used for estrus synchronization, pregnancy termination, and pyometra treatment.
Causes panting, salivation, vomiting, diarrhea, abdominal pain in small animals. Abortifacient — handle with gloves. Bronchoconstriction in asthmatics.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | SC | 0.025–0.25 mg/kg | q12-24h | Moderate | Smith FO. Pyometra. In: Bonagura JD, Twedt DC, eds. Kirk's Current Veterinary Therapy XV. Saunders Elsevier; 2014:967-969. / 10. Feldman E. The cystic endometrial hyperplasia/pyometra complex and infertility in female dogs. In: Ettinger S, Feldman E, eds. Textbook of Veterinary Internal Medicine: Diseases of the Dog and Cat. — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.434 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.