ExoticRx · exoticrx.com/drugs/riociguat
Adempas
Stimulates soluble guanylate cyclase (sGC) directly and sensitizes it to endogenous NO, increasing cGMP production and causing pulmonary vasodilation.
Do not combine with PDE5 inhibitors (sildenafil) or nitrates. Hypotension risk. Teratogenic. Investigational for pulmonary hypertension in dogs.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5–2 mg/kg | q8h | Weak | Veterinary Cardiology Literature Review |
| Cat (Domestic) | PO | 0.5–1.5 mg/kg | q8h | Extrapolated | Veterinary Cardiology Literature Review |
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