ExoticRx · exoticrx.com/drugs/riociguat
US brand names:Adempas
Stimulates soluble guanylate cyclase (sGC) directly and sensitizes it to endogenous NO, increasing cGMP production and causing pulmonary vasodilation.
Do not combine with PDE5 inhibitors (sildenafil) or nitrates. Hypotension risk. Teratogenic. Investigational for pulmonary hypertension in dogs.
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