ExoticRx · exoticrx.com/drugs/sacubitril-valsartan
US brand names:Entresto
Sacubitril-Valsartan is dosed at 0.5–3 mg/kg PO q12h in dogs, per JVIM 2021; Veterinary Cardiology Literature. Verify against current literature before clinical use.
Combines neprilysin inhibitor (sacubitril) with ARB (valsartan). Neprilysin inhibition increases natriuretic peptides promoting vasodilation and diuresis, while ARB blocks RAAS.
Do not combine with ACE inhibitors (angioedema risk). Monitor blood pressure and renal function. Emerging canine heart failure research.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.5–3 mg/kg | q12h | Weak | JVIM 2021; Veterinary Cardiology Literature |
| Cat (Domestic) | PO | 0.5–2 mg/kg | q12h | Extrapolated | JVIM 2021; Veterinary Cardiology Literature |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.