ExoticRx · exoticrx.com/drugs/sarolaner
US brand names:Simparica
Sarolaner is dosed at 2–4 mg/kg PO q30 days in dogs, per Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner in the treatment of canine ear mite infestation caused by Otodectes cynotis: a non-inferiority study. Vet Dermatol. 2018;29(2):100-e39. / 23. Six RH, Becskei C, Mazaleski MM, et al. Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis. Veterinary Parasitology. 2016;222:62-66. / 2. Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner against generalized demodicosis in dogs in European countries: a non-inferiority study. Vet Dermatol. 2018;29(3):203-e72. doi:10.1111/vde.12521 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1173 (2026-08-01).. Verify against current literature before clinical use.
Potent isoxazoline that inhibits GABA and glutamate-gated chloride channels in arthropod nervous system. Monthly flea, tick, and mite protection.
Seizure potential in dogs with neurologic history. Not for use in puppies <6 months. Effective against Demodex and Sarcoptes mites.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 2–4 mg/kg | q30 days | Strong | Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner in the treatment of canine ear mite infestation caused by Otodectes cynotis: a non-inferiority study. Vet Dermatol. 2018;29(2):100-e39. / 23. Six RH, Becskei C, Mazaleski MM, et al. Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis. Veterinary Parasitology. 2016;222:62-66. / 2. Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner against generalized demodicosis in dogs in European countries: a non-inferiority study. Vet Dermatol. 2018;29(3):203-e72. doi:10.1111/vde.12521 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1173 (2026-08-01). |
| Dog (Domestic) | PO | 2–4 mg/kg | q30 days | Moderate |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.