Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Sarolaner is dosed at 2–4 mg/kg PO q30 days in dogs, per Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner in the treatment of canine ear mite infestation caused by Otodectes cynotis: a non-inferiority study. Vet Dermatol. 2018;29(2):100-e39. / 23. Six RH, Becskei C, Mazaleski MM, et al. Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis. Veterinary Parasitology. 2016;222:62-66. / 2. Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner against generalized demodicosis in dogs in European countries: a non-inferiority study. Vet Dermatol. 2018;29(3):203-e72. doi:10.1111/vde.12521 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1173 (2026-08-01).. Sarolaner is used in dogs for Flea, tick, and mite prevention, Demodex mite treatment. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 2 cited dose rules for Sarolaner in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Simparica
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 2–4 mg/kg | q30 days | Monthly | Flea, tick, and mite prevention | Strong | Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner in the treatment of canine ear mite infestation caused by Otodectes cynotis: a non-inferiority study. Vet Dermatol. 2018;29(2):100-e39. / 23. Six RH, Becskei C, Mazaleski MM, et al. Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis. Veterinary Parasitology. 2016;222:62-66. / 2. Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner against generalized demodicosis in dogs in European countries: a non-inferiority study. Vet Dermatol. 2018;29(3):203-e72. doi:10.1111/vde.12521 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1173 (2026-08-01). |
| PO | 2–4 mg/kg | q30 days | Until 2 negative skin scrapes | Demodex mite treatment | Moderate | Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner in the treatment of canine ear mite infestation caused by Otodectes cynotis: a non-inferiority study. Vet Dermatol. 2018;29(2):100-e39. / 23. Six RH, Becskei C, Mazaleski MM, et al. Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis. Veterinary Parasitology. 2016;222:62-66. / 2. Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner against generalized demodicosis in dogs in European countries: a non-inferiority study. Vet Dermatol. 2018;29(3):203-e72. doi:10.1111/vde.12521 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1173 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Potent isoxazoline that inhibits GABA and glutamate-gated chloride channels in arthropod nervous system. Monthly flea, tick, and mite protection.
Seizure potential in dogs with neurologic history. Not for use in puppies <6 months. Effective against Demodex and Sarcoptes mites.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Sarolaner dose ranges in dogs, with cited source references: PO 2–4 mg/kg q30 days; PO 2–4 mg/kg q30 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Sarolaner in dogs: PO.
Cited course lengths for Sarolaner in dogs include: Monthly; Until 2 negative skin scrapes. Duration depends on the indication — match it to the specific dose rule in the table above.
Sarolaner is indicated in dogs for: Flea, tick, and mite prevention, Demodex mite treatment.
These are general warnings for Sarolaner across species; consult the dog dosing table above for species-specific guidance. Seizure potential in dogs with neurologic history. Not for use in puppies <6 months. Effective against Demodex and Sarcoptes mites.
Why a species-specific page? Sarolaner pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.