Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Sarolaner is dosed at 2–4 mg/kg PO q30 days in dogs, per Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner in the treatment of canine ear mite infestation caused by Otodectes cynotis: a non-inferiority study. Vet Dermatol. 2018;29(2):100-e39. / 23. Six RH, Becskei C, Mazaleski MM, et al. Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis. Veterinary Parasitology. 2016;222:62-66. / 2. Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner against generalized demodicosis in dogs in European countries: a non-inferiority study. Vet Dermatol. 2018;29(3):203-e72. doi:10.1111/vde.12521 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1173 (2026-08-01). — Plumb's 10th ed (held) printed p.1144, Sarolaner monograph spanning p.1144-1146; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207. Sarolaner is used in dogs for Demodex mite treatment. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Sarolaner in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Simparica
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|
| PO | 2–4 mg/kg | q30 days | Until 2 negative skin scrapes | Demodex mite treatment | Moderate | Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner in the treatment of canine ear mite infestation caused by Otodectes cynotis: a non-inferiority study. Vet Dermatol. 2018;29(2):100-e39. / 23. Six RH, Becskei C, Mazaleski MM, et al. Efficacy of sarolaner, a novel oral isoxazoline, against two common mite infestations in dogs: Demodex spp. and Otodectes cynotis. Veterinary Parasitology. 2016;222:62-66. / 2. Becskei C, Cuppens O, Mahabir SP. Efficacy and safety of sarolaner against generalized demodicosis in dogs in European countries: a non-inferiority study. Vet Dermatol. 2018;29(3):203-e72. doi:10.1111/vde.12521 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1173 (2026-08-01). — Plumb's 10th ed (held) printed p.1144, Sarolaner monograph spanning p.1144-1146; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 2–4 | — | BSAVA Small Animal Formulary, 10th ed — Part A (Canine and Feline)p.385 | 2-4 mg/kg. Administer every month. |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Potent isoxazoline that inhibits GABA and glutamate-gated chloride channels in arthropod nervous system. Monthly flea, tick, and mite protection.
Seizure potential in dogs with neurologic history. Not for use in puppies <6 months. Effective against Demodex and Sarcoptes mites.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Sarolaner dose range in dogs, with cited source references: PO 2–4 mg/kg q30 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Sarolaner in dogs: PO.
Cited course lengths for Sarolaner in dogs include: Until 2 negative skin scrapes. Duration depends on the indication — match it to the specific dose rule in the table above.
Sarolaner is indicated in dogs for: Demodex mite treatment.
These are general warnings for Sarolaner across species; consult the dog dosing table above for species-specific guidance. Seizure potential in dogs with neurologic history. Not for use in puppies <6 months. Effective against Demodex and Sarcoptes mites.
Why a species-specific page? Sarolaner pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.