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Sarolaner-Moxidectin-Pyrantel

Simparica Trio

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Antiparasitic

Routes

PO

Indications

Fleasheartwormintestinal parasitesticks

Mechanism of Action

Sarolaner (isoxazoline) inhibits GABA/glutamate channels in ectoparasites; moxidectin (macrocyclic lactone) targets nematode glutamate-gated chloride channels; pyrantel depolarizes nematode NMJ.

Side effects & warnings

Dogs only. Seizure risk in dogs with MDR1 mutation (moxidectin component). Do not use in dogs <8 weeks or <2.8 lbs. Monthly oral administration.

Species with Sarolaner-Moxidectin-Pyrantel dosing data (1 dose rule)

Dog (Domestic)

Species references:All Dog (Domestic) drugs

Evidence levels across 1 dose rule

Strong×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (1 of 1 cited rule)

A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO0 per labelq30 daysStrongPlumb's Veterinary Drug Handbook, 9th Ed

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