Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Sarolaner-Moxidectin-Pyrantel is used in dogs for Fleas, ticks, heartworm, intestinal parasites. Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Sarolaner-Moxidectin-Pyrantel in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Simparica Trio
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | Dosing: weight-based chewable | q30 days | Monthly, year-round | Fleas, ticks, heartworm, intestinal parasites | Strong | SIMPARICA TRIO - Sarolaner, Moxidectin, and Pyrantel Tablet, Chewable [US Product Label]. Zoetis Inc.; 2019. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0f83bcf4-7e89-479f-a980-4cb40456ee78 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.943 (2026-08-01). |
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Sarolaner (isoxazoline) inhibits GABA/glutamate channels in ectoparasites; moxidectin (macrocyclic lactone) targets nematode glutamate-gated chloride channels; pyrantel depolarizes nematode NMJ.
Dogs only. Seizure risk in dogs with MDR1 mutation (moxidectin component). Do not use in dogs <8 weeks or <2.8 lbs. Monthly oral administration.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Sarolaner-Moxidectin-Pyrantel dose range in dogs, with cited source references: PO Dosing: weight-based chewable q30 days. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Sarolaner-Moxidectin-Pyrantel in dogs: PO.
Cited course lengths for Sarolaner-Moxidectin-Pyrantel in dogs include: Monthly, year-round. Duration depends on the indication — match it to the specific dose rule in the table above.
Sarolaner-Moxidectin-Pyrantel is indicated in dogs for: Fleas, ticks, heartworm, intestinal parasites.
These are general warnings for Sarolaner-Moxidectin-Pyrantel across species; consult the dog dosing table above for species-specific guidance. Dogs only. Seizure risk in dogs with MDR1 mutation (moxidectin component). Do not use in dogs <8 weeks or <2.8 lbs. Monthly oral administration.
Why a species-specific page? Sarolaner-Moxidectin-Pyrantel pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.