Question 1

What is Solithromycin used for?

Accepted Answer

Solithromycin is indicated for: resistant infections, Respiratory, Respiratory infections.

Question 2

What routes can Solithromycin be administered by?

Accepted Answer

Available routes: PO, IV.

Question 3

Which species have cited Solithromycin dosing data?

Accepted Answer

Solithromycin dosing in the ExoticRx formulary covers 2 species: Cat (Domestic), Dog (Domestic).

Question 4

Is Solithromycin a controlled substance?

Accepted Answer

Solithromycin is not federally scheduled as a controlled substance, but is veterinary prescription only in most jurisdictions.

Question 5

What are the warnings or contraindications for Solithromycin?

Accepted Answer

Hepatotoxicity risk. QTc minimal. GI upset less than erythromycin. No veterinary data.

Question 6

What are the side effects of Solithromycin?

Accepted Answer

Reported side effects, adverse reactions, and contraindications for Solithromycin: Hepatotoxicity risk. QTc minimal. GI upset less than erythromycin. No veterinary data.

Question 7

How does Solithromycin work?

Accepted Answer

Binds 50S ribosomal subunit at three sites (vs. two for older macrolides). Overcomes macrolide resistance. Bacteriostatic.

Species	Route	Dose	Frequency	Evidence	Source
Dog (Domestic)	PO	5–10 mg/kg	q24h	Weak	Plumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)	PO	5–10 mg/kg	q24h	Weak	Plumb's Veterinary Drug Handbook, 9th Ed

Solithromycin

Drug Class

Routes

Indications

Mechanism of Action

Side effects & warnings

Species with Solithromycin dosing data (2 dose rules)

Evidence levels across 2 dose rules

Backed by a published source

Sample dosing (2 of 2 cited rules)

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