ExoticRx · exoticrx.com/drugs/topiramate
US brand names:Topamax
Topiramate is dosed at 2–10 mg/kg PO q8-12h in dogs, per Kiviranta AM, Laitinen-Vapaavuori O, Hielm-Bjorkman A, Jokinen T. Topiramate as an add-on antiepileptic drug in treating refractory canine idiopathic epilepsy. J Small Anim Pract. 2013;54(10):512-520. doi:10.1111/jsap.12130 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1285 (2026-08-01).. Verify against current literature before clinical use.
Multiple mechanisms: blocks voltage-gated sodium channels, enhances GABA-A activity, antagonizes AMPA/kainate glutamate receptors, inhibits carbonic anhydrase.
Used as adjunctive anticonvulsant. Sedation, ataxia. Metabolic acidosis (carbonic anhydrase inhibition). Weight loss. Renal stones. Limited veterinary data.
Species references:All Dog (Domestic) drugs
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| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 2–10 mg/kg | q8-12h | Weak | Kiviranta AM, Laitinen-Vapaavuori O, Hielm-Bjorkman A, Jokinen T. Topiramate as an add-on antiepileptic drug in treating refractory canine idiopathic epilepsy. J Small Anim Pract. 2013;54(10):512-520. doi:10.1111/jsap.12130 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1285 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.