Pocket Pet · Cavia porcellus · typical adult weight 0.70–1.20 kg
Trilostane is dosed at 2–4 mg/kg PO q12-24h in guinea pigs, per Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. / Zaheer OA, Beaufrere H. Treatment of hyperadrenocorticism in a guinea pig (Cavia porcellus). J Exot Pet Med. 2020;34:57-61. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.803 (2026-08-01, PENDING REVIEW). Trilostane is used in guinea pigs for Hyperadrenocorticism. Routes documented in guinea pigs: PO. A typical adult guinea pig weighs 0.70–1.20 kg. ExoticRx lists 1 cited dose rule for Trilostane in guinea pigs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Vetoryl
| Route | Dose | Frequency | Indication | Evidence | Source |
|---|---|---|---|---|---|
| PO | 2–4 mg/kg | q12-24h | Hyperadrenocorticism | Weak | Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. / Zaheer OA, Beaufrere H. Treatment of hyperadrenocorticism in a guinea pig (Cavia porcellus). J Exot Pet Med. 2020;34:57-61. — Mined from Carpenter's Exotic Animal Formulary, 6th Ed, p.803 (2026-08-01, PENDING REVIEW) |
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These ranges are per kg. Enter your guinea pig's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Competitively inhibits 3-beta-hydroxysteroid dehydrogenase, blocking conversion of pregnenolone to progesterone, thereby reducing cortisol synthesis.
First-line for canine Cushing's disease. Monitor with ACTH stimulation test. Adrenal necrosis reported (rare but serious). Hypoadrenocorticism risk. Give with food. Not for use in cats or pregnant animals.
Species-specific contraindications and adverse-reaction reports for guinea pigs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Trilostane dose range in guinea pigs, with cited source references: PO 2–4 mg/kg q12-24h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Trilostane in guinea pigs: PO.
Trilostane is indicated in guinea pigs for: Hyperadrenocorticism.
These are general warnings for Trilostane across species; consult the guinea pig dosing table above for species-specific guidance. First-line for canine Cushing's disease. Monitor with ACTH stimulation test. Adrenal necrosis reported (rare but serious). Hypoadrenocorticism risk. Give with food. Not for use in cats or pregnant animals.
Why a species-specific page? Trilostane pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in guinea pigs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.