Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Trilostane is dosed at 1–2.5 mg/kg PO q12h in dogs, per Lemetayer J, Blois S. Update on the use of trilostane in dogs. Canadian Veterinary Journal-Revue Veterinaire Canadienne. 2018;59:397-407. PMID: 37498128 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1304 (2026-08-01).. Trilostane is used in dogs for Hyperadrenocorticism (Cushing's disease). Routes documented in dogs: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Trilostane in dogs, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Vetoryl
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 1–2.5 mg/kg | q12h | Long-term (lifelong) | Hyperadrenocorticism (Cushing's disease) | Strong | Lemetayer J, Blois S. Update on the use of trilostane in dogs. Canadian Veterinary Journal-Revue Veterinaire Canadienne. 2018;59:397-407. PMID: 37498128 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1304 (2026-08-01). |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Competitively inhibits 3-beta-hydroxysteroid dehydrogenase, blocking conversion of pregnenolone to progesterone, thereby reducing cortisol synthesis.
First-line for canine Cushing's disease. Monitor with ACTH stimulation test. Adrenal necrosis reported (rare but serious). Hypoadrenocorticism risk. Give with food. Not for use in cats or pregnant animals.
Species-specific contraindications and adverse-reaction reports for dogs may differ from canine / feline reference data — consult the primary citations listed with each rule.
Trilostane dose range in dogs, with cited source references: PO 1–2.5 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Trilostane in dogs: PO.
Cited course lengths for Trilostane in dogs include: Long-term (lifelong). Duration depends on the indication — match it to the specific dose rule in the table above.
Trilostane is indicated in dogs for: Hyperadrenocorticism (Cushing's disease).
These are general warnings for Trilostane across species; consult the dog dosing table above for species-specific guidance. First-line for canine Cushing's disease. Monitor with ACTH stimulation test. Adrenal necrosis reported (rare but serious). Hypoadrenocorticism risk. Give with food. Not for use in cats or pregnant animals.
Why a species-specific page? Trilostane pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dogs — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.