ExoticRx · exoticrx.com/drugs/trilostane
Vetoryl
Competitively inhibits 3-beta-hydroxysteroid dehydrogenase, blocking conversion of pregnenolone to progesterone, thereby reducing cortisol synthesis.
First-line for canine Cushing's disease. Monitor with ACTH stimulation test. Adrenal necrosis reported (rare but serious). Hypoadrenocorticism risk. Give with food. Not for use in cats or pregnant animals.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–2.5 mg/kg | q12h | Strong | Plumb's Veterinary Drug Handbook, 9th Ed |
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