ExoticRx · exoticrx.com/drugs/trilostane
US brand names:Vetoryl
Trilostane is dosed at 2–4 mg/kg PO q12-24h in guinea pigs, per Meredith A. BSAVA Small Animal Formulary: Part B: Exotic Pets, British Small Animal Veterinary Association, Quedgeley, Gloucester, UK; 2015. / Zaheer OA, Beaufrere H. Treatment of hyperadrenocorticism in a guinea pig (Cavia porcellus). J Exot Pet Med. 2020;34:57-61. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.803 — Carpenter's Exotic Animal Formulary 6th ed, Table 9.7 (Miscellaneous Agents Used in Rodents). Verify against current literature before clinical use.
Competitively inhibits 3-beta-hydroxysteroid dehydrogenase, blocking conversion of pregnenolone to progesterone, thereby reducing cortisol synthesis.
First-line for canine Cushing's disease. Monitor with ACTH stimulation test. Adrenal necrosis reported (rare but serious). Hypoadrenocorticism risk. Give with food. Not for use in cats or pregnant animals.
Species references:All African Pygmy Hedgehog drugsAll Dog (Domestic) drugsAll Guinea Pig drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 3 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–2.5 mg/kg | q12h | Strong | Lemetayer J, Blois S. Update on the use of trilostane in dogs. Canadian Veterinary Journal-Revue Veterinaire Canadienne. 2018;59:397-407. PMID: 37498128 — Plumb's 10th ed printed p.1275, Trilostane monograph spanning p.1275-1278. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.