ExoticRx · exoticrx.com/drugs/trilostane
US brand names:Vetoryl
Trilostane is dosed at 2 mg/kg PO q24h in african pygmy hedgehogs, per 30. Jepson L. Hedgehogs. In: Jepson L, eds. Exotic Animal Medicine: A Quick Reference Guide, 2nd ed., Elsevier, St. Louis, MO; 2016:198-230. — Source: Carpenter's Exotic Animal Formulary, 6th Ed, p.745 — Carpenter's Exotic Animal Formulary 6th ed, Table 8.7 (Miscellaneous Agents Used in Hedgehogs). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — SOURCE EDITION: Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Verify against current literature before clinical use.
Competitively inhibits 3-beta-hydroxysteroid dehydrogenase, blocking conversion of pregnenolone to progesterone, thereby reducing cortisol synthesis.
First-line for canine Cushing's disease. Monitor with ACTH stimulation test. Adrenal necrosis reported (rare but serious). Hypoadrenocorticism risk. Give with food. Not for use in cats or pregnant animals.
Species references:All African Pygmy Hedgehog drugsAll Dog (Domestic) drugsAll Guinea Pig drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 3 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–2.5 mg/kg | q12h | Strong | Lemetayer J, Blois S. Update on the use of trilostane in dogs. Canadian Veterinary Journal-Revue Veterinaire Canadienne. 2018;59:397-407. PMID: 37498128 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1304 (2026-08-01). — Plumb's 10th ed (held) printed p.1275, Trilostane monograph spanning p.1275-1278; page located 2026-08-05 from the book's own running heads, verified to name the drug in its body text. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207 |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.