ExoticRx · exoticrx.com/drugs/trilostane
US brand names:Vetoryl
Trilostane is dosed at 1–2.5 mg/kg PO q12h in dogs, per Lemetayer J, Blois S. Update on the use of trilostane in dogs. Canadian Veterinary Journal-Revue Veterinaire Canadienne. 2018;59:397-407. PMID: 37498128 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1304 (2026-08-01).. Verify against current literature before clinical use.
Competitively inhibits 3-beta-hydroxysteroid dehydrogenase, blocking conversion of pregnenolone to progesterone, thereby reducing cortisol synthesis.
First-line for canine Cushing's disease. Monitor with ACTH stimulation test. Adrenal necrosis reported (rare but serious). Hypoadrenocorticism risk. Give with food. Not for use in cats or pregnant animals.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–2.5 mg/kg | q12h | Strong | Lemetayer J, Blois S. Update on the use of trilostane in dogs. Canadian Veterinary Journal-Revue Veterinaire Canadienne. 2018;59:397-407. PMID: 37498128 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1304 (2026-08-01). |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.