Pocket Pet · Oryctolagus cuniculus · typical adult weight 1.00–5.00 kg
Trimethoprim is dosed at 15–30 mg/kg PO q12h in rabbits, per Plumb DC. Plumb’s Veterinary Drug Handbook, 9th — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.845 (2026-08-01). — Carpenter's Exotic Animal Formulary 6th ed, Table 10.1 (Antimicrobial Agents Used in Rabbits.a). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — EDITION NOTE 2026-08-06: this rule's Plumb's reference names the 9th edition, which is not held and was never consulted. The held copy is the 10th ed (2023). The Plumb's line was never confirmed against the held edition, so rely on it only as background; any other source named in this citation is unaffected. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929. Trimethoprim is used in rabbits for Respiratory/urinary infections. Routes documented in rabbits: PO. A typical adult rabbit weighs 1.00–5.00 kg. ExoticRx lists 1 cited dose rule for Trimethoprim in rabbits, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Tribrissen
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO |
| 15–30 mg/kg |
| q12h |
| 7-14 days |
| Respiratory/urinary infections |
| Moderate |
| Plumb DC. Plumb’s Veterinary Drug Handbook, 9th — Verified against Carpenter's Exotic Animal Formulary, 6th Ed, p.845 (2026-08-01). — Carpenter's Exotic Animal Formulary 6th ed, Table 10.1 (Antimicrobial Agents Used in Rabbits.a). The copy held is an ebook conversion with no printed page numbers, so the table — not the page — is the citable location. — EDITION NOTE 2026-08-06: this rule's Plumb's reference names the 9th edition, which is not held and was never consulted. The held copy is the 10th ed (2023). The Plumb's line was never confirmed against the held edition, so rely on it only as background; any other source named in this citation is unaffected. — SOURCE EDITION: Plumb's Veterinary Drug Handbook — ISBN 9781394172207, https://openlibrary.org/isbn/9781394172207; Carpenter's Exotic Animal Formulary — ISBN 9780323833929, https://openlibrary.org/isbn/9780323833929 |
Every held source for this drug and species, as printed. Where they differ, both are shown — the choice is yours, not ours.
The sources disagree for this combination. The ranges below do not overlap on a comparable route. This is not an error in one of them — published veterinary references differ, and reconciling them for a particular patient is a clinical judgement.
| Dose (mg/kg) | Route | Source | As printed |
|---|---|---|---|
| 30 | PO | BSAVA Small Animal Formulary, 10th ed — Part B (Exotic Pets)p.305 | 30 mg/kg p.o., s.c. q24h; Guinea pigs, Chinchillas, Hamsters: 15-30 mg/kg p.o., i.m., s.c. q12-24h |
| 15–30 | PO | BSAVA Small Animal Formulary, 10th ed — Part B (Exotic Pets)p.305 | mg/kg p.o., s.c. q24h; Guinea pigs, Chinchillas, Hamsters: 15-30 mg/kg p.o., i.m., s.c. q12-24h; Rats, Mice, Gerbils: 50-100 mg/kg p.o., s.c. q24h |
| 50–100 | PO | BSAVA Small Animal Formulary, 10th ed — Part B (Exotic Pets)p.305 | 15-30 mg/kg p.o., i.m., s.c. q12-24h; Rats, Mice, Gerbils: 50-100 mg/kg p.o., s.c. q24h |
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These ranges are per kg. Enter your rabbit's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Inhibits dihydrofolate reductase (DHFR) in folate synthesis pathway. Synergistic bactericidal activity when combined with sulfonamides.
Almost always used in combination with a sulfonamide. Folate supplementation recommended in cats and during pregnancy. KCS risk in dogs.
Species-specific contraindications and adverse-reaction reports for rabbits may differ from canine / feline reference data — consult the primary citations listed with each rule.
Trimethoprim dose range in rabbits, with cited source references: PO 15–30 mg/kg q12h. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Trimethoprim in rabbits: PO.
Cited course lengths for Trimethoprim in rabbits include: 7-14 days. Duration depends on the indication — match it to the specific dose rule in the table above.
Trimethoprim is indicated in rabbits for: Respiratory/urinary infections.
These are general warnings for Trimethoprim across species; consult the rabbit dosing table above for species-specific guidance. Almost always used in combination with a sulfonamide. Folate supplementation recommended in cats and during pregnancy. KCS risk in dogs.
Why a species-specific page? Trimethoprim pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in rabbits — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.
| 15 | PO | Carpenter's Exotic Animal Formulary, 6th edTable 10.1 | 15 mg/kg PO q12h 30 mg/kg PO, SC, IM q12h |
| 30–48 | SC | Carpenter's Exotic Animal Formulary, 6th edTable 10.1 | 15-30 mg/kg PO q12-24h 30-48 mg/kg SC q12h |
| 30 | PO | Carpenter's Exotic Animal Formulary, 6th edTable 10.1 | 15 mg/kg PO q12h 30 mg/kg PO, SC, IM q12h |
| 15–30 | PO | Carpenter's Exotic Animal Formulary, 6th edTable 10.1 | 15-30 mg/kg PO q12-24h 30-48 mg/kg SC q12h |
Figures are transcribed from the cited page or table of each held edition and are shown for reference only. They are not dose recommendations, they do not feed the calculator, and none has been reviewed by a veterinarian.