Tulathromycin

Mechanism of Action

Novel triamilide macrolide with extremely long tissue half-life. Concentrates in pulmonary epithelial lining fluid and macrophages.

Species with Tulathromycin dosing data (2 dose rules)

Species references:All Goat (Caprine) drugsAll Sheep (Ovine) drugs

Evidence levels across 2 dose rules

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by 2 published sources

• · Grismer B, Rowe JD, Carlson J, Wetzlich SE, Tell LA. Pharmacokinetics of tulathromycin in plasma and milk samples after a single subcutaneous injection in lactating goats (Capra hircus). J Vet Pharmacol Ther. 2014;37(2):205-208. / Romanet J, Smith GW, Leavens TL, et al. Pharmacokinetics and tissue elimination of tulathromycin following subcutaneous administration in meat goats. Am J Vet Res. 2012;73:1634-1640. doi:10.1111/jvp.12071 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1311 (2026-08-01).
• · Washburn K, Fajt VR, Coetzee JF, Rice S, Wulf LW, Washburn S. Pharmacokinetics of tulathromycin in nonpregnant adult ewes. J Vet Pharmacol Ther. 2015;38(4):414-416. doi:10.1111/jvp.12196 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1310 (2026-08-01).