ExoticRx · exoticrx.com/drugs/zafirlukast
US brand names:Accolate
Zafirlukast is dosed at 1–5 mg/kg PO q12h in dogs, per Plumb's Veterinary Drug Handbook, 9th Ed. Verify against current literature before clinical use.
Competitive CysLT1 receptor antagonist blocking leukotriene D4 and E4 effects. Reduces bronchoconstriction and airway inflammation.
Give on empty stomach (food reduces absorption by 40%). Hepatotoxicity rare but monitor liver enzymes. CYP2C9 inhibitor — drug interactions. Limited vet data.
Species references:All Dog (Domestic) drugs
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A dog/cat sample is shown here. Cited dosing for all 1 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 1–5 mg/kg | q12h | Weak | Plumb's Veterinary Drug Handbook, 9th Ed |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.