Dog · Canis lupus familiaris · typical adult weight 2.00–80.00 kg
Zonisamide is used in dog for Epilepsy (adjunctive). Routes documented in dog: PO. A typical adult dog weighs 2.00–80.00 kg. ExoticRx lists 1 cited dose rule for Zonisamide in dog, drawn from published veterinary references. Verify against current literature before clinical use.
Trade names: Zonegran
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| PO | 5–10 mg/kg | q12h | Long-term | Epilepsy (adjunctive) | Moderate | Plumb's Veterinary Drug Handbook, 9th Ed |
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These ranges are per kg. Enter your dog's weight to get the precise dose and draw-up volume — unit and concentration math done for you.
Multiple mechanisms: blocks voltage-gated sodium and T-type calcium channels, enhances GABA release, and has mild carbonic anhydrase inhibitory activity.
Second-line anticonvulsant or add-on therapy. Sedation, ataxia, GI upset. Decreased appetite in some dogs. Renal tubular acidosis reported (rare). Monitor serum levels. Dogs and cats.
Species-specific contraindications and adverse-reaction reports for dog may differ from canine / feline reference data — consult the primary citations listed with each rule.
Why a species-specific page? Zonisamide pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in dog — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.