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Acetohydroxamic Acid

Lithostat

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Urinary

Routes

PO

Indications

Struvite urolithiasisStruvite urolithiasis (urease-positive UTI)

Mechanism of Action

Irreversibly inhibits bacterial urease, preventing hydrolysis of urea to ammonia. Reduces urine pH and prevents struvite stone formation.

Side effects & warnings

Teratogenic — do not use in pregnant animals. GI upset and hemolytic anemia possible. Monitor CBC. Not a substitute for antibiotics in UTI.

Species with Acetohydroxamic Acid dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs

Evidence levels across 2 dose rules

Moderate×1Weak×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO12.5 mg/kgq12hModeratePlumb's Veterinary Drug Handbook, 9th Ed
Cat (Domestic)PO12.5 mg/kgq12hWeakPlumb's Veterinary Drug Handbook, 9th Ed

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