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DL-Methionine

Methio-Form, Ammonil

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Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Urinary

Routes

PO

Indications

Urinary acidificationUrinary acidification (struvite prevention)

Mechanism of Action

Essential amino acid metabolized to sulfuric acid, lowering urine pH. Acidic urine inhibits struvite crystal formation and some bacterial growth.

Side effects & warnings

Contraindicated in cats with hepatic lipidosis or metabolic acidosis. Monitor urine pH regularly. Overdose can cause Heinz body anemia in cats.

Species with DL-Methionine dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs

Evidence levels across 2 dose rules

Moderate×2

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · Plumb's Veterinary Drug Handbook, 9th Ed

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Cat (Domestic)PO200–500 mg/cat totalq12hModeratePlumb's Veterinary Drug Handbook, 9th Ed
Dog (Domestic)PO25–50 mg/kgq8hModeratePlumb's Veterinary Drug Handbook, 9th Ed

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