ExoticRx · exoticrx.com/drugs/alosetron
US brand names:Lotronex
Alosetron is dosed at 0.01–0.05 mg/kg PO q12h in dogs, per Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use.. Verify against current literature before clinical use.
Selective serotonin 5-HT3 receptor antagonist that inhibits visceral afferent activity, reducing colonic motility and secretion.
Risk of ischemic colitis and severe constipation. Very restricted use in human medicine. Minimal veterinary data — investigational only.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | PO | 0.01–0.05 mg/kg | q12h | Weak | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
| Cat (Domestic) | PO | 0.01–0.04 mg/kg | q12h | Extrapolated | Source not established. The citation previously shown here named no retrievable document; a literature search on 2026-07-31 found no source that states this dose for this species and route. Treat as unverified and confirm against a primary reference before clinical use. |
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View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.