Skip to main content

Alosetron

Lotronex

Calculate dosage
Sourced from published veterinary references. Awaiting credentialed clinical reviewer — our editorial process.

Drug Class

Gastrointestinal

Routes

PO

Indications

Severe chronic diarrheaSevere diarrhea-predominant IBS

Mechanism of Action

Selective serotonin 5-HT3 receptor antagonist that inhibits visceral afferent activity, reducing colonic motility and secretion.

Side effects & warnings

Risk of ischemic colitis and severe constipation. Very restricted use in human medicine. Minimal veterinary data — investigational only.

Species with Alosetron dosing data (2 dose rules)

Cat (Domestic)Dog (Domestic)

Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs

Evidence levels across 2 dose rules

Weak×1Extrapolated×1

Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.

Backed by a published source

  • · Veterinary Gastroenterology Literature Review

Sample dosing (2 of 2 cited rules)

A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.

SpeciesRouteDoseFrequencyEvidenceSource
Dog (Domestic)PO0.01–0.05 mg/kgq12hWeakVeterinary Gastroenterology Literature Review
Cat (Domestic)PO0.01–0.04 mg/kgq12hExtrapolatedVeterinary Gastroenterology Literature Review

Upgrade for Full Details

Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.

View Plans

More Gastrointestinal drugs

Calculate Dosage for Alosetron