ExoticRx · exoticrx.com/drugs/apraclonidine-ophthalmic
US brand names:Iopidine
Selective alpha-2 adrenergic agonist that reduces aqueous humor production and enhances uveoscleral outflow, lowering intraocular pressure.
Tachyphylaxis develops with chronic use — best for short-term IOP reduction. May cause conjunctival blanching. Minimal systemic absorption.
Species references:All Cat (Domestic) drugsAll Dog (Domestic) drugs
Each ExoticRx dose rule is graded by the strength of its primary evidence — see the editorial process.
A dog/cat sample is shown here. Cited dosing for all 2 species — reptiles, birds, pocket pets, livestock, and equine — is free on the per-species pages above. Pro adds the weight-based calculator for every species.
| Species | Route | Dose | Frequency | Evidence | Source |
|---|---|---|---|---|---|
| Dog (Domestic) | Ophthalmic | Use for short-term IOP spike management | 1 drop affected eye q8h-q12h | Moderate | Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.1370 (2026-08-01). |
| Cat (Domestic) | Ophthalmic | Diagnostic test for Horner syndrome | 1 drop each eye; observe at 20, 45 min | Moderate | Gelatt KN, Veterinary Ophthalmology, 6th Ed |
Upgrade to Pro or Student to unlock the full dose ranges and frequency for every species. The drug's mechanism, warnings, indications, and cited sources are free to read.
View PlansSource citations and evidence levels available on the live page. Reference only — verify against current literature before clinical use.