Livestock · Bos taurus · typical adult weight 250.00–900.00 kg
Cloprostenol Sodium (Livestock) is dosed at 0.5 mg total IM single dose in cattle, per ESTRUMATE- Cloprostenol Sodium Injection [US Product Label]. Merck Sharp & Dohme Corp.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=634a706f-4a00-4a04-86ae-a4d8c22b8271 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.327 (2026-08-01).. Cloprostenol Sodium (Livestock) is used in cattle for Estrus synchronization, luteolysis, Estrus synchronization, pyometra. Routes documented in cattle: IM. A typical adult cattle weighs 250.00–900.00 kg. ExoticRx lists 2 cited dose rules for Cloprostenol Sodium (Livestock) in cattle, drawn from published veterinary references. Verify against current literature before clinical use.
US trade names: Estrumate, estroPLAN
| Route | Dose | Frequency | Duration | Indication | Evidence | Source |
|---|---|---|---|---|---|---|
| IM | 0.5 mg total | single dose | — | Estrus synchronization, luteolysis | Strong | ESTRUMATE- Cloprostenol Sodium Injection [US Product Label]. Merck Sharp & Dohme Corp.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=634a706f-4a00-4a04-86ae-a4d8c22b8271 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.327 (2026-08-01). |
| IM | 500 mcg total dose | Per protocol | 1-2 injections | Estrus synchronization, pyometra | Strong | ESTRUMATE- Cloprostenol Sodium Injection [US Product Label]. Merck Sharp & Dohme Corp.; 2018. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=634a706f-4a00-4a04-86ae-a4d8c22b8271 — Verified against Plumb's Veterinary Drug Handbook, 10th Ed, p.327 (2026-08-01). |
Need the exact dose for your patient?
Enter your cattle's weight to check these cited ranges in the calculator — unit and concentration math done for you.
Synthetic analogue of prostaglandin F2-alpha. More potent and longer-acting than natural dinoprost. Causes luteolysis and return to estrus in cattle and horses.
Women of childbearing age should handle with extreme caution. Absorbed through skin. Fewer side effects than dinoprost in horses. IM injection only.
Species-specific contraindications and adverse-reaction reports for cattle may differ from canine / feline reference data — consult the primary citations listed with each rule.
Cloprostenol Sodium (Livestock) dose ranges in cattle, with cited source references: IM 0.5 mg total single dose; IM 500 mcg total dose Per protocol. Reference ranges from cited sources — verify against current literature before clinical use.
Documented routes for Cloprostenol Sodium (Livestock) in cattle: IM.
Cited course lengths for Cloprostenol Sodium (Livestock) in cattle include: 1-2 injections. Duration depends on the indication — match it to the specific dose rule in the table above.
Cloprostenol Sodium (Livestock) is indicated in cattle for: Estrus synchronization, luteolysis, Estrus synchronization, pyometra.
These are general warnings for Cloprostenol Sodium (Livestock) across species; consult the cattle dosing table above for species-specific guidance. Women of childbearing age should handle with extreme caution. Absorbed through skin. Fewer side effects than dinoprost in horses. IM injection only.
Why a species-specific page? Cloprostenol Sodium (Livestock) pharmacokinetics differ across species: dose ranges, intervals, and route preferences are not interchangeable. Cross-extrapolation from canine doses is unsafe in cattle — the rules above are the citations specific to this species, not generic recommendations.
Sourced from published veterinary references; awaiting credentialed clinical reviewer. See our editorial process. Reference only — not veterinary advice.